https://doi.org/10.4081/hls.2024.12751
Evaluation of the therapeutic potential and safety of Al Hayat black cumin seed oil: an observational study
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Published: 9 October 2024
The purpose of this study was to investigate the therapeutic potential and safety of the use of Al Hayat black cumin seed oil. Descriptive and discrete statistical methods and frequency analysis were applied. There were 20 participants in total aged between 11 and 67 years, both men and women. The participants were divided into three subgroups, each receiving different doses of black cumin oil: 10 mg/kg, 20 mg/kg, and 30 mg/kg, respectively. Such parameters as general blood count, liver enzyme activities (aspartate aminotransferase and alanine aminotransferase), creatinine, and serum iron levels were analysed. A dose of 10 mg/kg was found to have no significant therapeutic or adverse effect. A dosage of 20 mg/kg demonstrated positive effects on platelet, immune cell, and creatinine values with no significant side effects. A dose of 30 mg/kg is not recommended for use due to the high risk of adverse reactions. The author also found no significant differences in the therapeutic effects and adverse reactions to black cumin oil that could be related to the gender or age of the participants.
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Dosoky NS, Setzer WN. Maternal reproductive toxicity of some essential oils and their constituents. Int J Mol Sci 2021;22:2380. DOI: https://doi.org/10.3390/ijms22052380
Ojah EO. Medicinal plants: Prospective drug candidates against the dreaded Coronavirus. Iberoam J Med 2020;2:314-21. DOI: https://doi.org/10.53986/ibjm.2020.0055
Khadka D, Dhamala MK, Li F, et al. The use of medicinal plants to prevent COVID-19 in Nepal. J Ethnobiol Ethnomed 2021;17:26. DOI: https://doi.org/10.1186/s13002-021-00449-w
Riaz M, Khalid R, Afzal M, et al. Phytobioactive compounds as therapeutic agents for human diseases: A review. Food Sci Nutr 2023;11:2500-29. DOI: https://doi.org/10.1002/fsn3.3308
Guo M, Qin S, Wang S, et al. Herbal medicine nanocrystals: A potential novel therapeutic strategy. Molecules 2023;28:6370. DOI: https://doi.org/10.3390/molecules28176370
Choudhury A, Singh PA, Bajwa N, et al. Pharmacovigilance of herbal medicines: Concerns and future prospects. J Ethnopharmacol 2023;309:116383. DOI: https://doi.org/10.1016/j.jep.2023.116383
Ramalingam K, Ittiyavirsh S, Kuttan R, et al. Safety assessment of a thymoquinone-rich black cumin (Nigella sativa) oil (BlaQmax®): Acute and sub-chronic toxicity studies. J Nutr Food Sci 2021;11:811.
Telci I, Izgi MN, Ozek T, et al. Effects of different nitrogen doses on thymoquinone and fatty acid composition in seed oil of black cumin (Nigella sativa L.). J Am Oil Chem Soc 2022;99:229-37. DOI: https://doi.org/10.1002/aocs.12570
Ghane ET, Poormohammadi A, Khazaei S, Mehri F. Concentration of potentially toxic elements in vegetable oils and health risk assessment: A systematic review and meta-analysis. Biol Trace Elem Res 2022;200:437-46. DOI: https://doi.org/10.1007/s12011-021-02645-x
Lammari N, Louaer O, Meniai AH, et al. Plant oils: From chemical composition to encapsulated form use. Int J Pharm 2021;601:120538. DOI: https://doi.org/10.1016/j.ijpharm.2021.120538
Hosni R, Haffez H, Elkordy H. Common applications of black cumin seed (Nigella sativa) oil in folk medicine. J Adv Pharm Res 2023;7:1-14. DOI: https://doi.org/10.21608/aprh.2022.166251.1196
Akaberi T, Akaberi M, Farhadi F, Ahmad S. Black Cumin Seeds: From ancient medicine to current clinical trials. In: Atta-ur-Rahman, Choudhary MI, Yousuf S, eds. Science of Spices and Culinary Herbs – Latest Laboratory, Pre-clinical, and Clinical Studies. Sharjah: Bentham Science Publisher; 2021. pp 27-59. DOI: https://doi.org/10.2174/9789814998154121050004
Aliiev RB. Features of the endocrine activity of fat tissue in metabolism disorders. Bull Med Biol Res 2023;15:26-32.
Bernstein N, Akram M, Yaniv-Bachrach Z, Daniyal M. Is it safe to consume traditional medicinal plants during pregnancy? Phytother Res 2021;35:1908-24. DOI: https://doi.org/10.1002/ptr.6935
Kahssay SW, Tadege G, Muhammed F. Self-medication practice with modern and herbal medicines and associated factors among pregnant women attending antenatal care at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia. Heliyon 2022;8:e10398. DOI: https://doi.org/10.1016/j.heliyon.2022.e10398
Shahini E, Luhovyi S, Kalynychenko H, et al. Rational use of oilseed waste to increase dairy productivity. Int J Environ Stud 2023;80:442-50. DOI: https://doi.org/10.1080/00207233.2022.2147727
Chen Y, Xu Y, Han X, et al. Azacytidine shows potential in controlling the chilling injury of banana peel during cold storage. Food Control 2024;159:110283. DOI: https://doi.org/10.1016/j.foodcont.2023.110283
Balarastaghi S, Delirrad M, Jafari A, et al. Potential benefits versus hazards of herbal therapy during pregnancy; A systematic review of available literature. Phytother Res 2022;36:824-41. DOI: https://doi.org/10.1002/ptr.7363
Zarrouk A, Martine L, Grégoire S, et al. Profile of fatty acids, tocopherols, phytosterols and polyphenols in Mediterranean oils (argan oils, olive oils, milk thistle seed oils and nigella seed oil) and evaluation of their antioxidant and cytoprotective activities. Curr Pharm Des 2019;25:1791-805. DOI: https://doi.org/10.2174/1381612825666190705192902
Nikolova NS, Danyliv SI. Analysis of fatty oil Nigella sativa L. produced in Ukraine and Bulgaria. Bull Med Biol Res 2022;4:80-3. DOI: https://doi.org/10.11603/bmbr.2706-6290.2022.1.12831
Hannan A, Rahman A, Sohag AAM, et al. Black cumin (Nigella sativa L.): A comprehensive review on phytochemistry, health benefits, molecular pharmacology, and safety. Nutrients 2021;13:1784. DOI: https://doi.org/10.3390/nu13061784
Mukhametov A, Aliyeva N, Musayeva N, et al. Antioxidant activity and phenolic content of cereal food concentrates: Import control issues. Agric Conspec Sci 2023;88:317-24.
Yimer EM, Tuem KB, Karim A, et al. Nigella sativa L. (black cumin): A promising natural remedy for wide range of illnesses. Evid Based Complement Alternat Med 2019;1528635. DOI: https://doi.org/10.1155/2019/1528635
Novak-Mazepa CO, Sachuk NV, Marushchak MI. Analysis of factors associated with arterial hypertension and the quality of patients’ life. Bull Med Biol Res 2023;5:60-7.
Ermumcu MSK, Şanlıer N. Black cumin (Nigella sativa) and its active component of thymoquinone: Effects on health. J Food Health Sci 2017;3:170-83. DOI: https://doi.org/10.3153/JFHS17020
Chen Y, Li D, Zhang X, et al. Azacytidine-induced hypomethylation delays senescence and coloration in harvested strawberries by stimulating antioxidant enzymes and modulating abscisate metabolism to minimize anthocyanin overproduction. Food Chem 2023;407:135189. DOI: https://doi.org/10.1016/j.foodchem.2022.135189
Kurmanova A, Urazbayeva G, Terlikbayeva A, et al. Diagnostic significance of blood lymphocyte activation markers in pre-eclampsia. Clin Exp Immunol 2024;215:94-103. DOI: https://doi.org/10.1093/cei/uxad121
Svyatova G, Berezina G, Danyarova L, et al. Genetic predisposition to gestational diabetes mellitus in the Kazakh population. Diabetes Metab Syndr 2022;16:102675. DOI: https://doi.org/10.1016/j.dsx.2022.102675
Salyha N. Regulation of oxidative stress and lipid peroxidation induced by epinephrine: The corrective role of L-Glutamic acid. Int J Med Med Res 2023;9:32-8. DOI: https://doi.org/10.61751/ijmmr.2413-6077.2023.1.32
Ilderbayev O, Okassova A, Rakhyzhanova S, et al. The levels of oxidative stress in a combination of stress factors. J Med Life 2022;15:927-31. DOI: https://doi.org/10.25122/jml-2021-0060
Kudabayeva KI, Bazargaliev YS, Darzhanova KB, Agzamova RT. Peculiarities of chronic gastritis in diabetes mellitus type 2. Eur J Phys Health Educ 2014;6:1-5.
Thomas JV, Mohan ME, Prabhakaran P, et al. A phase I clinical trial to evaluate the safety of thymoquinone-rich black cumin oil (BlaQmax®) on healthy subjects: Randomized, double-blinded, placebo-controlled prospective study. Toxicol Rep 2022;9:999-1007. DOI: https://doi.org/10.1016/j.toxrep.2022.04.020
Salaria N, Kumari I, Neeraj, et al. Concept of polycystic ovarian syndrome: Anti-PCOS plants in the Unani system of medicines. In: Hajam YA, Kumar R, Thakur DR, Rai S, eds. Herbal Medicine Applications for Polycystic Ovarian Syndrome. Boca Raton: CRC Press; 2023. pp 128-48. DOI: https://doi.org/10.1201/9781003344728-5
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