Original Articles
Vol. 13 No. 1 (2025)
https://doi.org/10.4081/hls.2024.12723

The effectiveness of risperidone on PANSS score and IL-6 in confirmed COVID-19 schizophrenic patients

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Received: 15 June 2024
Accepted: 10 July 2024
Published: 22 July 2024
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COVID-19, risperidone, schizophrenia, positive and negative syndrome scale, Interleukin-6

Authors

Sonny Teddy Lisal
Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Hawaidah Hawaidah
Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Dessy Natalia
dessynatalia.psychiatry@gmail.com
https://orcid.org/0009-0008-0918-0366
Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Arifin Seweng
Department of Biostatistics, Faculty of Public Health, Universitas Hasanuddin, Makassar, Indonesia.
Yuyun Widaningsih
Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Erlyn Limoa
Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Saidah Syamsuddin
Department of Psychiatry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

The study aimed to determine the efficacy of risperidone on PANSS scores and Interleukin 6 (IL-6) levels in schizophrenia patients with confirmed COVID-19. The study type was analytical observational, with a prospective cohort design. The subjects included inpatient Schizophrenia patients with and without COVID-19, mild-moderate and asymptomatic COVID-19, and schizophrenic patients without COVID-19 who were hospitalized and met the inclusion and exclusion criteria, for a total of 22 subjects in each group. The Positive and Negative Syndrome Scale (PANSS) and Elisa Interleukin 6 (IL-6) serum were sampled consecutively for this study. In the positive covid-19 group, the Mean IL-6 Post was significantly lower than Pre (23.0 vs. 26.1, p<0.001), while in the control group, the Mean IL-6 Post (four weeks) was significantly lower than Pre (baseline), with 19.3 vs. 21.0 (p<0.001). Serum IL-6 levels appeared to be an effective prognostic biomarker in COVID-19 patients. The 35 pg/mL cut-off point could distinguish mild-moderate patients from more severe ones. We discovered that schizophrenia patients with verified positive COVID-19 received COVID-19 therapy in the form of a combination of antipsychotic and antivirals had IL-6 levels lower than 35 pg/mL, indicating the role of antipsychotic (risperidone) and antiviral in reducing IL-6 levels.

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The effectiveness of risperidone on PANSS score and IL-6 in confirmed COVID-19 schizophrenic patients. (2024). Healthcare in Low-Resource Settings, 13(1). https://doi.org/10.4081/hls.2024.12723
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