<i>Helicobacter Pylori</i> infection and non-alcoholic fatty liver disease. Is there a relationship?

Neveen Rashad Mostafa; Abeer A.M. Ali; Mona Gamalludin Alkaphoury; Roy Rillera Marzo

doi:10.4081/hls.2023.11379

Authors

Neveen Rashad Mostafa
doctor.aj.2000@gmail.com
Department of Experimental and Clinical Internal Medicine, Medical Research Institute, Alexandria University, Egypt. https://orcid.org/0000-0001-6499-812X
Abeer A.M. Ali Department of Chemical Pathology, Medical Research Institute, Alexandria University, Egypt.
Mona Gamalludin Alkaphoury Department of Diagnostic Radiology, Ain Shams University, Egypt. https://orcid.org/0000-0002-1797-9898
Roy Rillera Marzo Department of Community Medicine, International Medical School, Management and Science University, Shah Alam, Malaysia; Global Public Health, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Kuala Lumpur, Malaysia.

The most prevalent infection that causes chronic gastritis, gastric ulcers, and gastric cancer is Helicobacter pylori infection. Recent research has implicated H. pylori in the pathogenesis of non-gastrointestinal diseases such as cardiovascular, autoimmune, and metabolic disorders. In addition, since H. pylori is believed to be implicated in insulin resistance, numerous studies have been conducted to determine the relationship between H. pylori infection and nonalcoholic fatty liver diseases (NAFLD), but the results have been contested. The purpose of this study is to determine the relationship between H. Pylori infection and nonalcoholic fatty liver diseases. One hundred patients were examined via urea breath test for the presence of H. pylori infection and vibration-controlled transient elastography for the diagnosis of non-alcoholic fatty liver disease. After adjusting for other variables, age, body mass index (BMI), and H. pylori infection were associated with elastography 248dB/m. Infection with H. pylori contributes to the development of NAFLD, and its eradication may influence prognosis.

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Rashad Mostafa, N., Ali, A. A., Alkaphoury, M. G., & Marzo, R. R. (2023). <i>Helicobacter Pylori</i> infection and non-alcoholic fatty liver disease. Is there a relationship?. Healthcare in Low-Resource Settings, 11(s2). https://doi.org/10.4081/hls.2023.11379