McKittrick-Wheelock syndrome is a rare condition characterized by secretory diarrhea due to villous adenoma of the colon, acute renal failure, dehydration, electrolyte and acid-base disorders. Diagnosis requires high suspicion especially when the presentation is unusual. Although potentially fatal for its complications, if promptly diagnosed and treated it is completely reversible. We present a case of a 67-year-old man who presented with syncope and diarrhea. On admission arterial blood gas test showed a complex acid-base disorder that led clinicians to further investigations and to point out a correct diagnosis.
