Potentially toxic cyanobacteria blooms in the southern Alps and the Italian peninsula

Cyanobacteria and cyanotoxins: a long history of studies in Sardinia (Italy)

Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 20 May 2025
Accepted: 5 March 2026
Published: 11 November 2025
220
Views
192
Downloads
8
HTML

Authors

The aim of this review is to reconstruct the scientific research on cyanobacteria and cyanotoxins carried out in the artificial lakes of Sardinia (Italy), the second largest island in the Mediterranean Sea, over a period of about 50 years, from the 1970s to the present. The information contained in scientific articles in Web of Science and Scopus databases was analysed using specific keywords. In addition, scientific articles not included in the above-mentioned databases were considered if they were published after a peer review process or if they were available on the website of public institutions. The analysis resulted in the identification of 60 scientific papers containing information on cyanobacteria and/or cyanotoxins, leading to a list of 77 taxa signalled and four groups of cyanotoxins ascertained (microcystins, anatoxin, cylindrospermopsin; β-N-Methylamino-L-Alanine, BMAA). In addition to these results, we point out the research we are carrying out and would like to continue in the future, a future in which it will be extremely important to be able to juggle the expected progressive affirmation of cyanobacteria and related issues. We highlight the difficulty of finding scientific articles published before the 2000s in the most widely used databases (Web of Science and Scopus), despite the fact that the production is rich and cutting-edge compared to the period in which the research was carried out. Finally, we signal the importance of close collaboration between institutions to obtain the results reported, the overcoming of disciplinary boundaries and the development of a collaborative rather than competitive environment between different research groups in dealing with such complex topics.

Downloads

Download data is not yet available.
Abbiati M, Mistri M, Bartoli M, et al., 2010. Trade-off between conservation and exploitation of the transitional water ecosystems of the northern Adriatic Sea. Chem Ecol 26:105-19.
Aktan Y, Lugliè A, Sechi N, 2009. Morphological plasticity of dominant species in response to nutrients dynamics in Bidighinzu reservoir of Sardinia, Italy. Turk J Fish Aquat Sci 9:137-44.
Antunes JT, Leão PN, Vasconcelos VM, 2015. Cylindrospermopsis raciborskii: review of the distribution, phylogeography, and ecophysiology of a global invasive species. Front Microbiol 6:473.
Barbanti L, Sechi N, Cossu A, et al., 1979. Indagini limnologiche sul L. Omodeo (Sardegna Centrale). Act of the meeting “Bacini lacustri artificiali”, Sassari, 4-6 October 1977: 345-375. Book series of National Program “Promozione della qualità dell’ambiente”. C.N.R. AC/2/4-21.
Barroccu G, Venier A, 2004. Introduction. In: L. Guerrieri, I. Rischia, L. Serva (eds), APAT, Roma, Field trip guidebook series: Hydrogeology of the Island of Sardinia (Italy), 32nd International Geological Congress. Post congress 5:P37.
Boero F, 2022. Linking ecosystems, habitats, and biodiversity: from the grand picture to the tiny details, and back. Adv Oceanogr Limnol 13.
Borghero G, Pugliatti M, Marrosu F, et al., 2014. Genetic architecture of ALS in Sardinia. Neurobiol Aging 35:2882.e7-12.
Bresciani M, Giardino C, Stroppiana D, et al., 2019. Monitoring water quality in two dammed reservoirs from multispectral satellite data. Eur J Remote Sens 52:113-22.
Bresciani M, Vascellari M, Giardino C, Matta E, 2012. Remote sensing supports the definition of the water quality status of Lake Omodeo (Italy). Eur J Remote Sens 45:349-60.
Bruno M, Attard Barbini D, Pierdominici E, et al., 1994. Anatoxin-a and a previously unknown toxin in Anabaena planctonica from blooms found in Lake Mulargia (Italy). Toxicon 32:369-73.
Bruno M, Gucci PMB, Pierdominici E, et al., 1992. Microcystin-like toxins in different freshwater species of Oscillatoria. Toxicon 30:1307-17.
Burford MA, Beardall J, Willis A, et al., 2016. Understanding the winning strategies used by the bloom-forming cyanobacterium Cylindrospermopsis raciborskii. Harmful Algae 54:44-53.
Buscarinu P, Catani F, Dessena MA, et al., 2003. Assessing environmental sustainability: remote sensing and GIS as tools for water resources evaluation. Adv Ecol Sci 18:465-75.
Cattina G, 2005. Fioriture tossiche negli invasi della Sardegna. Diffusione delle fioriture algali tossiche nelle acque italiane: gestione del rischio ed evidenze epidemiologiche. In: Mattei D., Melchiorre S., Messineo V and Bruno M. (eds), Rapporti ISTISAN 05/29:11-6.
Contu A, Sechi N, Sarritzu G, et al., 1987. Eutrophication in water supply reservoirs: general impacts on potable water preparation. Wat. Sci. Tech. 19:1191-1193. Proceedings of I.A.W.P.R.C. 13th Conference. Rio de Janeiro, 17-22 August 1986.
Cossu A, Sechi N, 1989. La situazione trofica del lago di Oschiri. Atti del Convegno “La qualità dell'acqua in Sardegna. Il problema dell'eutrofizzazione: cause, conseguenze, rimedi”, Cagliari, 15-16 May 1986.
Fadda A, Manca M, Camin F, et al., 2016. Study on the suspended particulate matter of a Mediterranean artificial lake (Sos Canales Lake) using Stable Isotope Analysis of carbon and nitrogen. Ann Limnol - Int J Lim 52:401-12.
Fadda A, Padedda BM, Lugliè A, et al., 2014. Spatiotemporal dynamics of C and N isotopic signature of zooplankton: an annual study on a man-made lake in the Mediterranean Region. Ann Limnol-Int J Lim 50:279-87.
García-Ruiza José MJ, López-Morenoa I, Vicente-Serranoa SM, et al., 2011. Mediterranean water resources in a global change scenario. Earth Sci Rev 105:121-39.
Humbert JF, Quiblier C, Gugger M, 2010. Molecular approaches for monitoring potentially toxic marine and freshwater phytoplankton species. Anal Bioanal Chem 397:1723-32.
Huisman J, Codd GA, Paerl HW, et al., 2018. Cyanobacterial blooms. Nat Rev Microbiol 16:471.
Igwaran A, Kayode AJ, Moloantoa KM, et al., 2024. Cyanobacteria Harmful Algae Blooms: Causes, Impacts, and Risk Management. Water Air Soil Pollut 235:71.
Jakubowska N, Szeląg-Wasielewska E, 2015. Toxic Picoplanktonic Cyanobacteria - Review Mar Drugs 13:1497-518.
Lawrence RJ, Després C, 2004. Futures of Transdisciplinarity. Futures 36:397-405.
Lazzaro L, Essl F, Lugliè A, et al., 2018. Invasive alien plant impacts on human health and well-being. In: Mazza G, Tricarico E (eds.), Invasive Species and Human Health. CAB International, Boston, USA.
Legrand B, Miras Y, Beauger A, et al., 2019. Akinetes and ancient DNA reveal toxic cyanobacterial recurrences and their potential for resurrection in a 6700-year-old core from a eutrophic lake. Sci Total Environ 687:1369-80.
Loizzo A, Sechi N, Volterra L, Contu A, 1988. Some features of a bloom of Oscillatoria rubescens D.C. registered in two Italian reservoirs. Water, Air and Soil Pollut 38:263-71.
Loizzo A, Contu A, Sechi N, Volterra L, 1989. Studi tossicologici eseguiti dopo episodi di fioriture di alghe in Sardegna. Proceedings of the meeting “La qualità dell'acqua in Sardegna. Il problema dell’eutrofizzazione: cause, conseguenze, rimedi”, Cagliari-Quartu, 15-16 May 1986.
Lugliè A, Aktan Y, Casiddu P, Sechi N, 2001. The trophic status of Bidighinzu Reservoir (Sardinia) before and after the diversion of waste waters. J Limnol 60:135-42.
Lugliè A, Giacobbe MG, Riccardi E, et al., 2017. Paralytic Shellfish Toxins and cyanotoxins in the Mediterranean: new data from Sardinia and Sicily (Italy). Microorganisms 5:72.
Lugliè A, Mameli GP, Sechi N, 1996. Indagine limnologica pluriennale (dal 1991 al 1993) sul lago artificiale di Sos Canales (Sardegna Settentrionale). Proceedings of the 11° A.I.O.L. National Congress - Sorrento, 26-28 October 1994.
Lugliè A, Manca B, Sechi N, 1994. Limnologia degli invasi Pattada e Monteleone (Nord Sardegna). Proceedings of the 10° A.I.O.L. National Congress - Alassio, 4-6 November 1992.
Lugliè A, Manca B, Sechi N, 1996. Studi limnologici sul Lago Alto Flumendosa (Sardegna Centrale) stato trofico e fitoplancton. Boll Soc Sarda Sci Nat. 31:83-100.
Lugliè A, Pulina S, Bruno M, et al., 2015. Marine toxins and climate change: the case of PSP from cyanobacteria in coastal lagoons. In: L.M. Botana and A. Alfonso (eds), Phycotoxins: Chemistry and Biochemistry. 2nd edition. Wiley-Blackwell, Hoboken, USA.
Lugliè A, Sechi N, 1988. Indagini sullo stato trofico dei laghi artificiali della Sardegna: la situazione del Lago Gusana. Proceedings of the 8° A.I.O.L. National Congress - Pallanza, 1-3 June 1988.
Lugliè A, Sechi N, 1992. L’evoluzione trofica del Lago Mulargia dal 1985 al 1989. Proceedings of the 9° A.I.O.L. National Congress - S.Margherita Ligure, 20-23 November 1990.
Lugliè A, Sechi N, 1993. Trophic status and phytoplankton in Lake Bidighinzu. Giorn Bot Ital 127:765-85.
Lugliè A, Virdis T, Sechi N, 1998. Osservazioni limnologiche sul Lago Simbirizzi dal 1989 al 1993, con particolare riferimento alla dinamica del fitoplancton. Proceedings of the 12° A.I.O.L. National Congress – Isola di Vulcano, 18-21 September 1996.
Lyu H, Wang Q, Wu C, et al., 2013. Retrieval of phycocyanin concentration from remote-sensing reflectance using a semi-analytic model in eutrophic lakes. Ecol Inform 18:178-87.
Mameli R, Bazzoni AM, Casiddu P, Sechi N, 2002. Evoluzione dello stato trofico del Lago Pattada. Proceedings of the 15° A.I.O.L. National Congress – Garda (VR), 25-28 September 2000.
Manganelli M, Testai E, Codd GA, 2024. The complex relationship between cyanobacteria and antibiotics/antimicrobial resistance in the environment: an emerging factor in the One Health vision on antimicrobial resistance. Adv Oceanogr Limnol 15:12754.
Manganelli M, Viaggiu E, Barone R, et al., 2014. Situazione nazionale: corpi idrici interessati da cianobatteri tossici. In: Funari E, Manganelli M, Testai E (eds), Cianobatteri: linee guida per la gestione delle fioriture nelle acque di balneazione. Rapporti ISTISAN 14/20.
Manti G, Mattei D, Messineo V, et al., 2005. First report of Cylindrospermopsis raciborskii in Italy. Harmful Algae News 28:8-9.
Mariani MA, Lai GG, Padedda BM, et al., 2015a. Long-term ecological studies on phytoplankton in Mediterranean reservoirs: a case study from Sardinia (Italy). Inland Waters 5:339-54.
Mariani MA, Padedda BM, Kaštovský J, et al., 2015b. Effects of trophic status on microcystin production and the dominance of cyanobacteria in the phytoplankton assemblage of Mediterranean reservoirs. Sci Rep 5:10.1038/srep17964.
Mattei D, Stefanelli M, 2008. Distribuzione e fisiologia dei cianobatteri potenzialmente tossici in Italia. Istituto Superiore di Sanità, Cianobatteri potenzialmente tossici: aspetti ecologici, metodologici e valutazione del rischio. In: Funari E, Scardala S, Testai E (eds), ISTISAN 08/6:4-29.
Meregalli M, Trebini F, Manca B, Lugliè A, 2002. Stato trofico e fitoplancton nel Lago Alto Flumendosa. Proceedings of the 14° A.I.O.L. National Congress - Garda, 25-28 September 2000.
Meriluoto J, Blaha L, Bojadzija G, et al., 2017. Toxic cyanobacteria and cyanotoxins in European waters - recent progress achieved through the CYANOCOST Action and challenges for further research. Adv Oceanogr Limnol 8:6429.
Messineo V, Bogialli S, Melchiorre S, et al., 2009. Cyanotoxins occurrence in Italian freshwaters. Limnologica 39:95-106.
Messineo V, Bruno M, De Pace R, 2024. The Role of Cyano-HAB (Cyanobacteria Harmful Algal Blooms) in the One Health Approach to Global Health. Hydrobiol 3:238-62.
Montaldo N, Sirigu S, Zucca R, et al., 2024. Hydrological sustainability of dam-based water resources in a Mediterranean basin undergoing climate change. Hydrol 11:200.
Mura M, Sechi N, Lugliè A, 1992. L’evoluzione trofica del Lago Simbirizzi dal primo anno d’invaso (1986) al 1989. Proceedings of the 9° A.I.O.L. National Congress - S. Margherita Ligure, 20-23 November 1990.
Nair A, Sathyendranath S, Platt T, et al., 2008. Remote sensing of phytoplankton functional types. Remote Sens Environ 112:3366-75.
Noto LV, Cipolla G, Pumo D, Francipane A, 2023. Climate change in the Mediterranean basin (Part II): a review of challenges and uncertainties in climate change modelling and impact analyses. Water Resour Manag 37:2307-23.
One Health High-Level Expert Panel (OHHLEP), Adisasmito WB, Almuhairi S, et al., 2022. A new definition for a sustainable and healthy future. PLoS Pathog 18:e1010537.
Padedda BM, Buscarinu P, Caddeo T, et al., 2021. IT10-A Ecosistemi lacustri della Sardegna. In: Capotondi L, Ravaioli M, Acosta A, et al. (eds), La Rete Italiana per la Ricerca Ecologica di Lungo Termine. Lo studio della biodiversità e dei cambiamenti.
Padedda BM, Lugliè A, Pulina S, et al., 2012. Ecosistemi Lacustri della Sardegna. In: Bertoni R (eds), La rete italiana per la ricerca ecologica a lungo termine (LTER-Italia). Situazione e prospettive dopo un quinquennio di attività (2006-2011). ARACNE Editrice, Rome, Italy.
Padedda BM, Sechi N, Lai GG, et al., 2017. Consequences of eutrophication in the management of water resources in Mediterranean reservoirs: a case study of Lake Cedrino (Sardinia, Italy). Global Ecol Conserv 12:21-35.
Padedda BM, Lugliè A, Lai GG, et al., 2022. Land-based impact of nutrient loads and eutrophication on an ancient Mediterranean natural lake. Hydrol 9:7.
Padedda BM, Pulina S, Satta C, et al., 2019. Eutrophication and nutrient fluxes in Mediterranean coastal lagoons. In: P. Maurice (ed.), Encyclopedia of Water, Science, Technology, and Society.
Padedda BM, Sechi N, 2008. Condizioni del Lago Cedrino e relazioni con il suo bacino versante. Nat Sardegna 30:42-9.
Pulina S, Lugliè A, Mariani MA, et al., 2019. Multiannual decrement of nutrient concentrations and phytoplankton cell size in a Mediterranean reservoir. In: Mazzocchi MG, Capotondi L, Freppaz M, et al. (eds), Italian Long-Term Ecological Research for understanding ecosystem diversity and functioning. Case studies from aquatic, terrestrial and transitional domains. Nature Conservation 34: 163-91.
Pulina S, Stanca E, Lugliè A, et al., 2022. Phytoplankton cell geometric shapes along Mediterranean seasonal environmental variability in natural and artificial lakes. J Plankton Res 44:1-16.
Pulina S, Suikkanen S, Satta CT, et al., 2016. Multiannual phytoplankton trends in relation to environmental changes across aquatic domains: a case study from Sardinia (Mediterranean Sea). Plant Biosyst 150:660-70.
Rosati I, Bergami C, Stanca E, et al., 2017. A thesaurus for phytoplankton trait-based approaches: Development and applicability. Ecol Inform 42:129-38.
Salmaso N, Boscaini A, Capelli C, et al., 2015. Historical colonisation patterns of Dolichospermum lemmermannii (Cyanobacteria) in a deep lake south of the Alps. Adv Oceanog Limnol 6:33-45.
Satta CT, Angles S, Garcés E, et al., 2010. Dinoflagellate cysts in recent sediments from two semi-enclosed areas of the Western Mediterranean Sea subject to high human impact. Deep-Sea Res II: Top Stud Oceanogr 57:256-67.
Satta CT, Anglès S, Lugliè A, et al., 2013. Studies on dinoflagellate cyst assemblages in two estuarine Mediterranean bays: a useful tool for the discovery and mapping of harmful algal species. Harmful Algae 24:65-79.
Satta CT, Anglès S, Garcés E, et al., 2013. Dinoflagellate cyst assemblages in surface sediments from three shallow Mediterranean lagoons (Sardinia, North Western Mediterranean Sea). Estuaries Coasts 37:646-63.
Schenk K, Bernert H, Bauer P, 2021. Operational satellite-based high-resolution water quality products from for use cases around the world. Trends Earth Obs 2:162-5.
Sechi N, 1978. Struttura e biomassa dei popolamenti fitoplanctonici del Lago Omodeo (Sardegna Centrale). Giorn Bot Ital 112:347-60.
Sechi N, 1983. Il fitoplancton e lo stato trofico di alcuni laghi artificiali della Sardegna. Proceedings of the 4° A.I.O.L. National Congress - Chiavari, 1-3 December 1980.
Sechi N, 1986. Il problema dell'eutrofizzazione dei laghi. La situazione trofica degli invasi della Sardegna. Boll Soc Sarda Sci Nat 25:49-62.
Sechi N, 1992. Le problematiche legate al fitoplancton nelle acque lacustri destinate ad uso potabile. Giorn Bot Ital 126:237-51.
Sechi N, 2000. La struttura algale e lo stato trofico dei laghi della Sardegna. Workshop “Aspetti sanitari della problematica dei cianobatteri nelle acque superficiali italiane”. Istituto Superiore di Sanità; Roma; 16-17 dicembre 1999. In: Funari E (ed), Rapporti ISTISAN 00/30:101-10.
Sechi N, Buscarinu P, Lugliè A, 1994. Limnologia del nuovo invaso del Cixerri nei primi due anni di esistenza. Proceedings of the 10° A.I.O.L. National Congress - Alassio, 4-6 November 1992.
Sechi N, Buscarinu P, Pilo E, Lugliè A, 1998. Il fitoplancton del Lago Cixerri nei primi cinque anni di esistenza. Proceedings of the 12° A.I.O.L. National Congress – Isola di Vulcano, 18-21 September 1996.
Sechi N, Cossu A, Manca M, 1979. Il Lago Omodeo: caratteristiche fisiche e chimiche. Boll Soc Sarda Sci Nat 18:169-90.
Sechi N, Lugliè A, 1987. Le alghe planctoniche dell'invaso del Mulargia (Sardegna centro-meridionale) con particolare riferimento ad una fioritura prolungata di Oscillatoria rubescens D.C. in rapporto alle condizioni chimiche e fisiche. Proceedings of the 7° A.I.O.L. National Congress - Trieste 11-14 June 1986.
Sechi N, Lugliè A, 1989. Lo stato trofico dei Laghi Mulargia e Flumendosa. Atti del Convegno “La qualità dell’acqua in Sardegna. Il problema dell’eutrofizzazione: cause, conseguenze, rimedi” Cagliari, 15-16 maggio 1986.
Sechi N, Lugliè A, 1992. Limnological studies on man-made lakes in Sardinia (Italy). Mem Ist Ital Idrobiol 50:365-81.
Sechi N, Lugliè A, 1996. Phytoplankton in Sardinia reservoirs. Giorn Bot Ital 130:977-94.
Sechi N, Manca R, 1983. La comunità fitoplanctonica e lo stato trofico del Lago di Oschiri (Sardegna Settentrionale). Proceedings of the 4° A.I.O.L. National Congress - Chiavari, 1-3 December 1980.
Sechi N, Mosello R, 1985. Nutrient budget and trophic level of L. Oschiri (Sardinia, Italy). Mem Ist Ital Idrobiol 43:55-75.
Sechi N, Testoni GA, Urbani M, 1985. Fitoplancton, nutrienti e stato trofico del Lago Cuga (Sardegna Settentrionale). Proceedings of the 6° A.I.O.L. National Congress - Livorno 12-14 April 1984.
Secretariat of the Convention on Biological Diversity, 2004. The Ecosystem Approach, (CBD Guidelines). Secretariat of the Convention on Biological Diversity, Montreal, Canada; 50 pp.
Shi K, Zhang Y, Qin B, Zhou B, 2019. Remote sensing of cyanobacterial blooms in inland waters: present knowledge and future challenges. Sci Bull 64:1540-56.
Sini P, Dang TBC, Fais M, et al., 2021. Cyanobacteria, cyanotoxins, and neurodegenerative diseases: dangerous liaisons. Int J Mol Sci 22:8726.
Sini P, Galleri G, Ciampelli C, et al., 2024. Evaluation of cyanotoxin L-BMAA effect on a-synuclein and TDP43 proteinopathy. Front Immunol 15:1360068.
Stefanelli M, Scardala S, Cabras PA, et al., 2017. Cyanobacterial dynamics and toxins concentrations in Lake Alto Flumendosa, Sardinia, Italy. Adv Oceanog Limnol 8:6352.
Sulis A, Buscarinu P, Soru O, Sechi GM, 2014. Trophic state and toxic cyanobacteria density in optimization modelling of multi-reservoir water resource systems. Toxins 6:1366-84.
Topp SN, Pavelsky TM, Jensen D, et al., 2020. Research trends in the use of remote sensing for inland water quality science: moving towards multidisciplinary applications. Water 12:169.
Volk A, Lee J, 2023. Cyanobacterial blooms: a player in the freshwater environmental resistome with public health relevance? Environ Res 216:114612.
Volterra L, Aquilina G, Conti L, et al., 1986. A toxic bloom of Oscillatoria in Italy: uni- and multidosal predictive toxicometrics using in vivo and in vitro models. Proceedings of the Third International Conference of the Israel Society for ecology and environmental quality sciences, Jerusalem, 1-4 June 1986.
Wang Z, Chen Q, Zhang J, et al., 2020. Critical roles of cyanobacteria as reservoir and source for antibiotic resistance genes. Environ Int 144:106034.
Wilkinson M, Dumontier M, Aalbersberg I, et al., 2016. The FAIR Guiding Principles for scientific data management and stewardship. Sci Data 3:160018.
Xi H, Losa SN, Mangin A, et al., 2020. Global retrieval of phytoplankton functional types based on empirical orthogonal functions using CMEMS GlobColour merged products and further extension to OLCI data. Remote Sens Environ 240:111704.
Zepernick NN, Wilhelm SW, Bullerjahn GS, Paerl HW, 2022. Climate change and the aquatic continuum: a cyanobacterial comeback story. Environ Microbiol Rep 15:3-12.

How to Cite



Cyanobacteria and cyanotoxins: a long history of studies in Sardinia (Italy) . (2025). Advances in Oceanography and Limnology, 16(1). https://doi.org/10.4081/aiol.2025.14014