The role of magnetic resonance imaging in assessing venous vascular abnormalities in the head and neck: a demonstration of cerebrospinal venous insufficiency in a subset of multiple sclerosis patients


Submitted: 31 January 2015
Accepted: 30 March 2015
Published: 29 June 2015
Abstract Views: 2652
PDF: 781
HTML: 1408
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

  • E. Mark Haacke Magnetic Resonance Innovations, Inc.; Department of Radiology, Wayne State University, Detroit, MI, United States.
  • Sean K. Sethi Magnetic Resonance Innovations, Inc., Detroit, MI, United States.
  • Jing Jiang Magnetic Resonance Innovations, Inc., Detroit, MI, United States.
  • Ying Wang Magnetic Resonance Innovations, Inc., Detroit, MI, United States.
  • David T. Utriainen Magnetic Resonance Innovations, Inc., Detroit, MI, United States.
The study of chronic cerebrospinal venous insufficiency (CCSVI) and its impact on the development and progression of multiple sclerosis (MS) remains controversial. Although the initial thrust in evaluating CCSVI was with ultrasound, other modalities including magnetic resonance imaging (MRI) have been used to study venous vascular abnormalities. This review focuses on the findings of a number of past MRI studies including a look at a combined study of four previous works with a cohort of 559 MS patients regarding structure and function of the extra-cranial vasculature. Strengths and limitations of each paper are discussed which give insight into conflicting reports of venous abnormalities in MS patients and healthy controls. Guidelines for data acquisition and analysis for future studies related to extra-cranial structure and flow, both arterial and venous, are discussed. This includes the grading of stenosis of the internal jugular veins (IJVs) as well as normalized flows through major veins of the neck. The lack of agreement between most studies is likely due to inconsistent data acquisition and incomplete data analysis. Our own work over four independent sites shows good agreement, indicating that there is a high incidence of stenosis and structural venous abnormalities in the MS population and that this change results in reduced outflow of the IJVs and increased collateralization of venous return to the heart compared to healthy controls.

Supporting Agencies

Nathional Heart, Lung, and Blood Institute of the National Institues of Health

Haacke, E. M., Sethi, S. K., Jiang, J., Wang, Y., & Utriainen, D. T. (2015). The role of magnetic resonance imaging in assessing venous vascular abnormalities in the head and neck: a demonstration of cerebrospinal venous insufficiency in a subset of multiple sclerosis patients. Veins and Lymphatics, 4(1). https://doi.org/10.4081/vl.2015.5012

Downloads

Download data is not yet available.

Citations


Similar Articles

You may also start an advanced similarity search for this article.