Scientific Articles
Vol. 16 No. 2 (2011)
https://doi.org/10.4081/microscopie.2011.4979

Morphological and ultrastructural changes induced by essential oil of Melaleuca alternifolia on drug-sensitive and drug-resistant strains of Candida albicans

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Received: 15 January 2015
Published: 30 September 2011
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Candida albicans, natural products, multidrug resistance, tea tree oil, electron microscopy.

Authors

M. Colone
Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy.
N. Mastrangelo
Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy.
F. Mondello
Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
L. Toccacieli
Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy.
L. Cerqua
ASL AVEZ/SULM/AQ P.O. Tagliacozzo, L'Aquila, Italy.
A. Stringaro
annarita.stringaro@iss.it
Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy.
The essential oil of Melaleuca alternifolia (Tea Tree Oil: TTO) exhibits broad-spectrum antimicrobial activity. Here, we report the effects of TTO treatment against the yeast Candida albicans. Previous proliferation study showed that TTO was effective both on fluconazole-susceptible (3153) and on resistant isolate (AIDS68) strains of C. albicans. The cells of the two strains were treated with 1% TTO. The analysis was carried out by transmission and scanning electron microscopy to assess the changes induced by treatment both on the wall and the cell membrane of yeasts.

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Morphological and ultrastructural changes induced by essential oil of Melaleuca alternifolia on drug-sensitive and drug-resistant strains of Candida albicans. (2011). Microscopie, 16(2), 49-53. https://doi.org/10.4081/microscopie.2011.4979

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