LONG TERM NEURODEVELOPMENTAL OUTCOME IN A COHORT OF PRETERM INFANTS BORN AT GESTATIONAL AGE <32 WEEKS


Submitted: 18 April 2014
Accepted: 18 April 2014
Published: 31 December 2013
Abstract Views: 950
PDF: 790
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Authors

  • M.G. Gatti Department of Pediatrics, Obstetrics and reproduction Medicine, University of Siena, Italy.
  • S. Perrone Department of Pediatrics, Obstetrics and reproduction Medicine, University of Siena, Italy.
  • S. Badii Department of Pediatrics, Obstetrics and reproduction Medicine, University of Siena, Italy.
  • E. Becucci Department of Pediatrics, Obstetrics and reproduction Medicine, University of Siena, Italy.
  • G. Turrisi Department of Pediatrics, Obstetrics and reproduction Medicine, University of Siena, Italy.
  • M.G. Alagna Department of Pediatrics, Obstetrics and reproduction Medicine, University of Siena, Italy.
  • E. Giacchi Department of Pediatrics, Obstetrics and reproduction Medicine, University of Siena, Italy.
  • G. Buonocore Department of Pediatrics, Obstetrics and reproduction Medicine, University of Siena, Italy.
Advances in perinatal care have led to an increase in survival of preterm children but have also increased the risk of long-term sequelae, like neurodevelopmental impairment and behavioral or emotional disturbance. To investigate neurodevelopmental patterns of preterm infants born at S. Maria alle Scotte Hospital, Siena, Italy. 128 babies with gestational age (GA) ≤32 weeks were admitted in 2006-2008 to Siena Hospital; 105 infants survived and were followed until three years of age, corrected for prematurity. Neurodevelopmental follow up was performed using Bayley scale of Infant and Toddler Development IIIed that consisted of five scales: Cognitive (CS), Language (LS), Motor (MS), Social-Emotional (SES) and Adaptive Behavior Scale (ABS). Intraventricular haemorrhage (IVH) was associated with lower motor score (P<0,001). Babies with retinopathy of prematurity (ROP) showed a lower score in CS, LS, MS and SES Bayley’s items (respectively p≤0,01; p≤0,05; p≤0,01; p≤0,05). Multiple regression analysis indicated as predictors of neurological outcome: gestational age (GA) for poor cognitive (p=0,016), language (p=0,004) and social-emotional development (p<0,0001), IVH for poor motor (p<0,0001) and adaptive behavior development (p<0,0001), twinship for better language (p=0,001) and social-emotional development (p=0,003). Bronchopulmoanry dyspasia (BPD) and patent ductus arteriosus (PDA) had a negative effect on respectively cognitive development (p=0,049) and social-emotional development (p=0,023). ROP, BPD, IVH, PDA, and GA significantly contributes to poor neurological outcome in preterm infants. BPD and IVH are the best predictors being associated with the lowest scores at Bayley scales. Surprisingly, twinship appeared to be a protective factor.

Gatti, M., Perrone, S., Badii, S., Becucci, E., Turrisi, G., Alagna, M., Giacchi, E., & Buonocore, G. (2013). LONG TERM NEURODEVELOPMENTAL OUTCOME IN A COHORT OF PRETERM INFANTS BORN AT GESTATIONAL AGE <32 WEEKS. Journal of the Siena Academy of Sciences, 5(1), 53–58. https://doi.org/10.4081/jsas.2013.3834

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