FREE RADICAL-RELATED DISEASES: THE PREDICTIVE VALUE OF BIOMARKERS IN THE UMBILICAL CORD BLOOD


Submitted: 18 April 2014
Accepted: 18 April 2014
Published: 31 December 2013
Abstract Views: 909
PDF: 784
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Authors

  • S. Perrone Department of Developmental and Molecular Medicine, General Hospital “Santa Maria alle Scotte”, University of Siena, Italy.
  • M.G. Alagna Department of Developmental and Molecular Medicine, General Hospital “Santa Maria alle Scotte”, University of Siena, Italy.
  • M.S. Cori Department of Developmental and Molecular Medicine, General Hospital “Santa Maria alle Scotte”, University of Siena, Italy.
  • A. Santacroce Department of Developmental and Molecular Medicine, General Hospital “Santa Maria alle Scotte”, University of Siena, Italy.
  • S. Negro Department of Developmental and Molecular Medicine, General Hospital “Santa Maria alle Scotte”, University of Siena, Italy.
  • M.L. Tataranno Department of Developmental and Molecular Medicine, General Hospital “Santa Maria alle Scotte”, University of Siena, Italy.
  • M. Longini Department of Developmental and Molecular Medicine, General Hospital “Santa Maria alle Scotte”, University of Siena, Italy.
  • C. Felici Department of Developmental and Molecular Medicine, General Hospital “Santa Maria alle Scotte”, University of Siena, Italy.
  • F. Proietti Department of Developmental and Molecular Medicine, General Hospital “Santa Maria alle Scotte”, University of Siena, Italy.
  • A. Picardi Department of Developmental and Molecular Medicine, General Hospital “Santa Maria alle Scotte”, University of Siena, Italy.
  • G. Buonocore Department of Developmental and Molecular Medicine, General Hospital “Santa Maria alle Scotte”, University of Siena, Italy.
Despite recent advances in preterm newborns healthcare, the incidence of neonatal pathologies and disabilities still remain unacceptable high. The deficiency of antioxidant systems and the high free radicals (FRs) production may cause several neonatal diseases, such as Retinopathy of Prematurity (ROP), Bronchopulmonary Dysplasia (BPD), Necrotizing Enterocolitis (NEC), Patent Ductus Arteriosus (PDA), Periventricular Leukomalacia (PVL) and Intraventricular Hemorrhage (IVH), representing facets of the ‘Free Radical-Related Diseases’ (FRD). The aim of this study is to verify the association between FRD and blood levels of reliable oxidative stress (OS) biomarkers in preterm newborns. We enrolled 178 preterm newborns born consecutively at the General Hospital “Santa Maria alle Scotte” in Siena, between 23 and 34 weeks (30,36±2.97) of gestational age, with birth-weight from 430 to 2890 grams (1453±593). After birth, we evaluated in the cord blood the markers of potential risk of OS (Non Protein-Bound Iron, NPBI) and the markers of FR damage (Total Hydroperoxides, TH; Advanced Oxidation Protein Products, AOPP). For each newborn, we assessed the presence or absence of the following diseases, considering as FRD the presence of one at least: ROP, BPD, NEC, PDA, PVL, IVH. The univariate logistic regression showed a significant association between FRD and OS related markers. Risk assessment of FRD was higher in newborns with higher values of each OS marker: respectively TH (OR=1.013, p=0,000), AOPP (OR=1.017, p=0,036), NPBI (OR=1.077, p=0.039). Perinatal OS exposure is linked to the main diseases of prematurity. The evaluation of OS biomarkers in preterm newborns through the analysis of umbilical cord blood, can be useful and predictive for early identification of infants at risk for FRD in order to devise appropriate and timely prevention and treating strategies.

Perrone, S., Alagna, M., Cori, M., Santacroce, A., Negro, S., Tataranno, M., Longini, M., Felici, C., Proietti, F., Picardi, A., & Buonocore, G. (2013). FREE RADICAL-RELATED DISEASES: THE PREDICTIVE VALUE OF BIOMARKERS IN THE UMBILICAL CORD BLOOD. Journal of the Siena Academy of Sciences, 5(1), 49–52. https://doi.org/10.4081/jsas.2013.3833

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