Submitted: 18 April 2014
Accepted: 18 April 2014
Published: 31 December 2013
Abstract Views: 2701
PDF: 1184
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  • Vincenzo Berghella Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, United States.
  • Alessandro Ghidini Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington DC, United States.
  • Giancarlo Mari Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, College Of Medicine, Memphis, United States.
  • Mariarosaria Di Tommaso Department of Child and Woman’s Health, University of Florence, Careggi University Hospital, Florence, Italy.
  • Silvia Vannuccini Department of Molecular and Developmental Medicine, University of Siena, Italy.
  • Filiberto Maria Severi Department of Molecular and Developmental Medicine, University of Siena, Italy.
  • Felice Petraglia Department of Molecular and Developmental Medicine, University of Siena, Italy.
The development of Maternal-Fetal Medicine is contributing to an improvement of maternal well-being and of neonatal health, introducing a number of new and useful technologies. Advances in genomics in the field of prenatal screening and diagnosis allowed the discovery of fragments of cell-free fetal DNA in the maternal circulation and the use of chromosomal microarrays, which can test for microdeletions and microduplications in addition to aneuploidies. Color Doppler applications during pregnancy are expanding exponentially and Doppler flow velocity waveforms indices have provided important information from maternal, placental and fetal circulation with clinical implications. Ultrasound monitoring of fetal growth represents a fundamental tool to evaluate fetal wellbeing and several methods have been developed to improve fetal weight estimation accuracy. The combination of new biophysical and biochemical markers is enriching Maternal-Fetal Medicine and more research will allow to improve pregnancy outcome.

Berghella, V., Ghidini, A., Mari, G., Di Tommaso, M., Vannuccini, S., Severi, F. M., & Petraglia, F. (2013). THE MATERNAL-FETAL MEDICINE: AN UPDATE. Journal of the Siena Academy of Sciences, 5(1), 1–10.


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