Submitted: 12 April 2013
Accepted: 12 April 2013
Published: 1 December 2012
Abstract Views: 857
PDF: 956
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.


In 1994, with a statistical study of trinucleotide occurences per frame, D. Arquès and C. Michel identified the fol lowing set of 20 trin- ucleotides in the gene population of both eucaryotes E U K and procaryotes P RO: {AAC , AAT , AC C , ATC,ATT,CAG,CTC,CTG,GAA,GAC,GAG,GAT, GCC,GGC,GGT,GTA,GTC,GTT,TAC,TTC}.This
set of words of length three on the genetic alphabet A4 = {A, C, G, T } has remarkable properties: it is a self-complementary set, it is a circular code, it is maximal and it has the C3- property. This and other identifications of trinucleotide circular codes in different genomes in the last twenty years raised interest in the concept of trinucleotide circular code for genetics. In 2003 we found an efficient algorithm for testing the circularity of a trinucleotide code and in 2005 we found the list of al l 528 maximal self-complementary circular codes. In 2008 we presented a hierarchy of the self-complementary circular codes and in 2012 we presented a hierarchy of al l circular codes. These circular codes could permit the identification, either in paral lel with or substituting existing methods used by biologist, of as yet unknown coding regions of DNA. A hierarchy of tetranucleotide circular codes is one of our aims in the future. In this paper we begin the study of the unbordered tetranucleotides and of the “forbidden configurations” for tetranucleotides and we give a first result.



PlumX Metrics


Download data is not yet available.


How to Cite

Pirillo, G. (2012). SOME PROPERTIES OF TRINUCLEOTIDES AND TETRANUCLEOTIDES. Journal of the Siena Academy of Sciences, 4(1), 59.