SELECTIVE INFLUENCES IN THE B-CELL RECEPTOR IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN IN HAIRY CELL LEUKEMIA

Submitted: 10 January 2012
Accepted: 10 January 2012
Published: 10 January 2012
Abstract Views: 722
PDF: 962
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Hairy cell leukemia (HCL) is a rare, chronic B-cell neoplasm characterized by leukemic hairy cells (HCs) present in blood, bone marrow, and splenic red pulp, with atrophy of white pulp. Lymph node involvement is infrequent. HCL is typically associated with markers of activation, that include expression of CD25, CD11c, FMC7, and CD103 at high intensity. A distinctive feature of HCL is expression of multiple surface immunoglobulin (sIg) isotypes, although its prevalence in HCL is not fully mapped.

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Forconi, F., Amato, T., Sozzi, E., Cencini, E., Raspadori, D., & Lauria, F. (2012). SELECTIVE INFLUENCES IN THE B-CELL RECEPTOR IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN IN HAIRY CELL LEUKEMIA. Journal of the Siena Academy of Sciences, 1(1), 18–26. https://doi.org/10.4081/jsas.2009.352