150 | New strategies to counteract dopaminergic degeneration: in vitro and in vivo neurotrophic properties of a tetrahydro-isoquinoline derivative as a novel mGlu2/3 agonist/positive allosteric modulator: Miriana Scordino1, Giulia Urone1, Monica Frinchi1, Lucia Seidita1, Alessandra Montalbano2, Marilia Barreca2, Paola Barraja2, Maria Valeria Raimondi2, Roberta Bivacqua2, Fanny Malhaire3, Cyril Goudet3, Giuseppa Mudò1, Virginia Spanò2, Valentina Di Liberto1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy; 2Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 3IGF, Université de Montpellier, CNRS, INSERM, France. J Biol Res [Internet]. 2026 Mar. 31 [cited 2026 Apr. 17];99(s1). Available from: https://www.pagepressjournals.org/jbr/article/view/15402