027 | Exploring the cooperative effect of osilodrostat and mitotane in 3D spheroid models of adrenocortical carcinoma: Fabiola Vaglica1, Laura Tomasello1, Mattia Biondo2, Giuseppe Siragusa2, Giorgio Arnaldi1, Giuseppe Pizzolanti1|3, Valentina Guarnotta1 | 1Dept. of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo; 2Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies STEBICEF, University of Palermo; 3ATeN Center, Palermo, Italy. J Biol Res. 2026;99(s1). doi:10.4081/jbr.2026.15279