146 | Preventive Effect of Intranasal Lemon-Derived Nanovesicles in a High-Fat Diet Rat Model of Metabolic Syndrome: Modulation of Anxiety-Like Behavior and Survival Signalling Pathways: Andrea Giubilato1, Nicolò Ricciardi1, Valentina Di Liberto1, Miriana Scordino1, Giulia Urone1, Danila Di Majo1, Giuseppe Giglia1|4, Pierangelo Sardo1, Giuseppe Ferraro1, Riccardo Alessandro1|2|3, Stefania Raimondo1|2, Giuditta Gambino1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics BiND, University of Palermo, Section of Human Physiology, Biology and Genetics, Palermo, Italy; 2Navhetec Srl, Spinoff of the University of Palermo, Palermo, Italy; 3Institute for Biomedical Research and Innovation IRIB, National Research Council CNR, Palermo, Italy; 4Euro Mediterranean Institute of Science and Technology-IEMEST, Palermo, Italy. J Biol Res 2026, 99 (s1). https://doi.org/10.4081/jbr.2026.15398.