2026. 122 | Tangential flow filtration enables high-yield isolation and stable characterization of grape-derived extracellular vesicles for therapeutic application: Sabino Porro1|2, Tamer Esmail1|2, Francesca D’Ascanio1|2|3, Giulia Colasante1|2, Arianna Aquilini-Mummolo,1|2, Luana D’Onofrio1|2, Mariagiulia Filoso1|2, Ayesha Younas1|2, Isabel Maria Vallejo Bermudez4|5, Camilla Cichella1|2, Michela Battistelli6, Anna Piro7, Serena Veschi7, Serena Pilato7, Antonella Fontana7, Alessandro Cama7, Angelo Cichelli8, Paola Lanuti1|2, Federica Flamminii9 | 1Department of Medicine and Aging Sciences, University “G d’Annunzio” of Chieti-Pescara, Italy; 2Center for Advanced Studies and Technology CAST; 3Molecular Immunology Group CTS208 Department of Humanities, Law and Economics, Leonardo da Vinci University, Torrevecchia Teatina, Italy; 4Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain; 5Immunology and Allergy Group GC01, Maimonides Biomedical Research Institute of Cordoba IMIBIC, University of Cordoba, Reina Sofia University Hospital, Cordoba, Spain; 6Department of Biomolecular Sciences DISB University of Urbino Carlo Bo, Italy; 7Department of Pharmacy, University “G d’Annunzio” of Chieti-Pescara, Italy; 8Department of Innovative Technologies in Medicine & Dentistry, University “G d’Annunzio” of Chieti-Pescara, Italy; 9Department of Promotion of Human Sciences and Quality of Life, San Raffaele Telematic University, Rome, Italy. Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale. 99, s1 (Mar. 2026). DOI:https://doi.org/10.4081/jbr.2026.15374.