|Immunofluorescence staining of rainbow trout hepatocyte nuclei with monoclonal antibody 5D11 for polycyclic aromatic hydrocarbon-DNA adducts. Chantale André, Environnement Canada.|
The Journal of Xenobiotics publishes original studies concerning the beneficial (pharmacology) and detrimental effects (toxicology) of xenobiotics in all organisms. A xenobiotic (“stranger to life”) is defined as a chemical that is not usually found at significant concentrations or expected to reside for long periods in organisms. In addition to man-made chemicals, natural products could also be of interest if they have potent biological properties, special medicinal properties or that a given organism is at risk of exposure in the environment. Topics dealing with abiotic- and biotic-based transformations in various media (xenobiochemistry) and environmental toxicology are also of interest. Areas of interests include the identification of key physical and chemical properties of molecules that predict biological effects and persistence in the environment; the molecular mode of action of xenobiotics; biochemical and physiological interactions leading to change in organism health; pathophysiological interactions of natural and synthetic chemicals; development of biochemical indicators including new “-omics” approaches to identify biomarkers of exposure or effects for xenobiotics. Studies on the interaction of emerging nano- and biotechnological devices and drug-nanopolymers with living tissues are also of interest to the journal. In addition to research papers, short communications, reviews and mini-reviews, Journal of Xenobiotics will publish special issues dealing with the environmental, pharmaceutical and health impacts of new classes of chemicals. In this case, a special issue will be announced and provided at the journal’s web site. Special issues brought by international symposia or other scientific venues are also welcomed.