Vascular anomalies in the mesenteric circulation of patients with Crohn’s disease: a pilot study

  • Matilde Zamboni | wambazamba@icloud.com Department of Thoracic, Cardiac, and Vascular Sciences, Post Graduated School in Vascular Surgery, University of Padua, Italy. http://orcid.org/0000-0002-6750-919X
  • Maria Grazia Sibilla Department of Surgery, Unit of Translational Surgery, University-Hospital of Ferrara, Italy.
  • Roberto Galeotti Unit of Vascular and Interventional Radiology, University-Hospital of Ferrara, Italy.
  • Massimo Pedriali Unit of Anatomy, Histology and Pathological Citology, University-Hospital of Ferrara, Italy.
  • Simona Ascanelli Department of Surgery, Unit of Translational Surgery, University-Hospital of Ferrara, Italy.

Abstract

Crohn’s disease (CD) is a chronic inflammatory bowel disease and its pathogenesis is still not well understood. Previous studies suggested the possibility of the involvement of vascular system, but, todate, the mesenteric circulation has poor been investigated, especially in complicated CD cases requiring colectomy. We investigated the mesenteric circulation in a case-control pilot study, including 19 controls and 7 patients affected by complicated cases of CD. Cases and controls underwent selective angiography of both superior and inferior mesenteric district. Transit time was found either significantly shortened in 2/7 cases (29%), or prolonged 5/7 (71%) (P=0.0034 in the superior mesenteric district; P=0.0079 in the inferior mesenteric district), respectively due to the presence of A-V malformations and of a miscellaneous of venous abnormalities, which included thrombosis, hypoplasia and extra-truncular venous malformations. Our study demonstrates the presence of congenital or acquired vascular anomalies in a small sample of CD patients not responder to current treatment and with severe complications. The present pilot study warrants further investigations.

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Published
2017-07-31
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Original Articles
Keywords:
Crohn’s disease, mesenteric circulation, angiography, AV malformations.
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How to Cite
Zamboni, M., Sibilla, M. G., Galeotti, R., Pedriali, M., & Ascanelli, S. (2017). Vascular anomalies in the mesenteric circulation of patients with Crohn’s disease: a pilot study. Veins and Lymphatics, 6(2). https://doi.org/10.4081/vl.2017.6817