Vascular anomalies in the mesenteric circulation of patients with Crohn’s disease: a pilot study


Submitted: 26 May 2017
Accepted: 14 July 2017
Published: 31 July 2017
Abstract Views: 1930
PDF: 453
HTML: 230
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Crohn’s disease (CD) is a chronic inflammatory bowel disease and its pathogenesis is still not well understood. Previous studies suggested the possibility of the involvement of vascular system, but, todate, the mesenteric circulation has poor been investigated, especially in complicated CD cases requiring colectomy. We investigated the mesenteric circulation in a case-control pilot study, including 19 controls and 7 patients affected by complicated cases of CD. Cases and controls underwent selective angiography of both superior and inferior mesenteric district. Transit time was found either significantly shortened in 2/7 cases (29%), or prolonged 5/7 (71%) (P=0.0034 in the superior mesenteric district; P=0.0079 in the inferior mesenteric district), respectively due to the presence of A-V malformations and of a miscellaneous of venous abnormalities, which included thrombosis, hypoplasia and extra-truncular venous malformations. Our study demonstrates the presence of congenital or acquired vascular anomalies in a small sample of CD patients not responder to current treatment and with severe complications. The present pilot study warrants further investigations.

Zamboni, M., Sibilla, M. G., Galeotti, R., Pedriali, M., & Ascanelli, S. (2017). Vascular anomalies in the mesenteric circulation of patients with Crohn’s disease: a pilot study. Veins and Lymphatics, 6(1). https://doi.org/10.4081/vl.2017.6817

Downloads

Download data is not yet available.

Citations