Chronic cerebro-spinal insufficiency in multiple sclerosis and meniere disease: same background, different patterns?

  • Pietro Maria Bavera Vascular Imaging Diagnostician for Medick-Up Vascular Lab, Milan; Department of Clinical Sciences, University of Milan, and Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Federica Di Berardino IRCCS S. Maria Nascente don Carlo Gnocchi Foundation, Milan, Italy.
  • Piero Cecconi Department of Clinical Sciences, University of Milan, and Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Laura Mendozzi Department of Clinical Sciences, University of Milan, and Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Valentina Mattei Department of Clinical Sciences, University of Milan, and Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Dario Carlo Alpini | vertigoschool5@gmail.com Department of Clinical Sciences, University of Milan, and Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan; Vertigo School, Milan, Italy.

Abstract

Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by demyelinating lesions with acute phases and progressive loss of sensorimotor functions. Mèniére disease (MD) is a disorder of the inner ear characterized by acute spells of vertigo and hearing loss and progressive loss of cochleo-vestibular function. Both the diseases have a multifactorial pathogenesis and quite the same chronic cerebro-spinal insufficiency (CCSVI) frequency. However, as far as Author’s knowledge concerns, no patients affected with both diseases are described so far. The aim of this paper is to investigate whether MS and MD present different CCSVI patterns. Three groups of patients were enrolled: 60 definite MS - 27 definite unilateral MD (MEN) - 41 with other no-Mèniére, audiovestibular disorders (OVD). All subjects underwent magnetic resonance venography (MRV) and venous Duplex (ECD) and only patients that satisfied both MRV and ECD CCSVI diagnostic criteria were considered. J1 was normal in 57% of MS, 88% of MEN and 95% of OVD. Stenosis (ST) were detected, respectively, in 30% of MS and 2% in MEN and OVD. J2 was normal in 78% of MS, 64% of MEN and 95% of OVD. At this level alterations of the trunk (AT) were detected in 17% in MS and 26% in MEN; J3 was normal in 74% of MS, 64% of MEN and 86% of OVD. AT were found in 15% of MS, 26% of MEN and 8% of OVD. Hyperplasia of the Vertebral Veins was observed in 35% of MS, 40% of MEN and in 15% of OVD. Other compensatory collaterals were detected in 25% in MS and only in 5% in MEN and OVD. Our results indicate that the MS pattern is characterized by J1 stenosis, J2 trunk alterations, a prevalence of J1-J2 medial-distal alterations, compensatory collaterals besides vertebral venous system. MD pattern is characterized by trunk alteration in J3, a prevalence of J3- J2 medial-proximal alterations and vertebral veins hyperplasia without other detectable collaterals. Although the group of patients with venous alterations is very small, OVD patients show a CCSVI pattern that is more similar to MD than MS pattern. The difference between MS and MD patterns indicates that CCSVI is not a unique entity and it could be an explanation of the fact that subjects affected with both the diseases are not reported.

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Author Biographies

Pietro Maria Bavera, Vascular Imaging Diagnostician for Medick-Up Vascular Lab, Milan; Department of Clinical Sciences, University of Milan, and Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan
Vascular Imaging Diagnostician
Federica Di Berardino, IRCCS S. Maria Nascente don Carlo Gnocchi Foundation, Milan
researcher
Piero Cecconi, Department of Clinical Sciences, University of Milan, and Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan
neuroradiologist
Laura Mendozzi, Department of Clinical Sciences, University of Milan, and Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan
Neurologist
Valentina Mattei, Department of Clinical Sciences, University of Milan, and Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan
audiologist
Dario Carlo Alpini, Department of Clinical Sciences, University of Milan, and Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan; Vertigo School, Milan
ENT-Otoneurology Sewrvice Consultant
Published
2017-05-10
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Original Articles
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Keywords:
Chronic cerebro-spinal insufficiency, vertebral veins, multiple sclerosis, Mèniére disease.
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How to Cite
Bavera, P. M., Di Berardino, F., Cecconi, P., Mendozzi, L., Mattei, V., & Alpini, D. C. (2017). Chronic cerebro-spinal insufficiency in multiple sclerosis and meniere disease: same background, different patterns?. Veins and Lymphatics, 6(2). https://doi.org/10.4081/vl.2017.6533