Effective prophylaxis of visual and neurological disturbances with an anti-endothelin drug: analysis of 1642 sclerotherapy sessions

  • Alessandro Frullini | info@venevaricose.it Studio flebologico, Figline Incisa Valdarno (FI), Italy.
  • Angelo Guastini Private practice, Chiavari (GE), Italy.
  • Demetrio Guarnaccia Vascular Surgery, Clinica Santa Lucia, San Giuseppe vesuviano (NA), Italy.
  • O. Walter Loparco Studio flebologico, Pescara, Italy.
  • Domenico Maurano A.O. Cosenza, Italy.
  • Sabino Paradiso Centro Medico Paradiso, Trani, Italy.
  • Antonio M. Previtera Specialist in Angiology and Cardiology, Catania, Italy.
  • Michele Rendace Vascular Surgery, A.S.P. Cosenza, Italy.
  • Serafino Viviani Private practice, Castelnuovo Garfagnana (LU), Italy.
  • Patrizia Pavei U.O.C. Day Surgery Multidisciplinare, A.O. Padova, Italy.

Abstract

In the literature cases of stroke and transient neurological symptoms have been described after sclerotherapy for chronic venous disease The initial interpretation of these phenomena was that of a micro air embolism in association with a patent foramen ovale. This explanation did not always manage to justify all neurological manifestations. Recent theories have demonstrated that in the area of sclerosis, a significant amount of endothelin 1. We carried out a retrospective assessment of sclerotherapy case studies on 540 patients at ten phlebological centres to search for a relationship between the use of aminaftone (a venotropic drug with demonstrated anti-endothelin action) and the occurrence of side effects after sclerotherapy was performed. Significant reduction of side effects was observed in sclerotherapy for teleangectasias and in patients with migraine history.

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Published
2016-12-07
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Original Articles
Keywords:
Chronic venous disease, foam sclerotherapy, endothelin 1, visual and neurological complications.
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How to Cite
Frullini, A., Guastini, A., Guarnaccia, D., Loparco, O. W., Maurano, D., Paradiso, S., Previtera, A. M., Rendace, M., Viviani, S., & Pavei, P. (2016). Effective prophylaxis of visual and neurological disturbances with an anti-endothelin drug: analysis of 1642 sclerotherapy sessions. Veins and Lymphatics, 5(2). https://doi.org/10.4081/vl.2016.5764