https://www.pagepressjournals.org/index.php/tmr/issue/feed Translational Medicine Reports 2019-08-30T15:19:51+02:00 Francesca Baccino francesca.baccino@pagepress.org Open Journal Systems <p><strong>Translational Medicine Reports</strong> is a peer-reviewed international journal publishing articles in the field of molecular biology, biochemistry and nanotechnology applied to the treatment of chronic-degenerative diseases including diabetes, cancer, neurological, cardiovascular and metabolic disorders. Aim of the Journal is to contribute to bridging the gap between basic research and clinical applications from an interdisciplinary perspective. <strong>Translational Medicine Reports</strong> addresses researchers and managers in academia, biotechnology and pharmaceutical industry researchers, physician scientists, <em>etc.</em> Original Articles with interdisciplinary topics, Reviews, Editorials, From Bench-to-Bedside Articles, Conference Proceedings, and Letters to the Editor are welcome. Every article published in the Journal will be peer-reviewed by experts in the field and selected by members of the Editorial Board.&nbsp;</p> <p><strong>The journal is completely free: no charge for publication, as it is supported by private funds.</strong></p> https://www.pagepressjournals.org/index.php/tmr/article/view/8418 An atypical manifestation of lymph node tuberculosis: a case report 2019-08-30T15:19:51+02:00 Stefania De Luca stefaniadeluca02@gmail.com Giuliano Sequino giuseq@gmail.com Flavia Oliva flavia.oliva@arubapec.it Roberto Varriale varrialeroberto89@gmail.com Giovanni Motta giovannimotta95@yahoo.com Viviana Allocca vivi.allocca@tiscali.it Maria Cardone cardone.maria@virgilio.it Marco Perrella marco.perrel@virgilio.it Filippo Ricciardiello filipporicciardiello@virgilio.it <p>Tuberculosis is a chronic granulomatous infection caused by Mycobacterium tuberculosis. Since the 80’s the new cases have been increasing especially in developed countries because of spreading of HIV-infection, immunodeficiency and immigration phenomenon. Cervical lymphadenitis is the most frequent localization of extrapulmonary tuberculosis. Clinical manifestations consist in a slow growth and painless swelling of a single or multiple neck nodes, generally unilateral, with rare manifestations of fistulization and of systemic symptoms. Diagnosis is performed by FNAC or excisional biopsy integrated by Ziehl-Neelsen stain and Mycobacteria culture. A 57-year-old male patient affected by a right-side large laterocervical swelling. The patient referred that almost one month before he noted the onset of the lesion sizing about 1 cm, so he treated it with antibiotic association of amoxicillin and clavulanate acid without any improvement. The lesion quickly doubled its size, became painful and hyperemic the skin above it. Because of the clinical worsening, the patient undergone to neck ultrasonography that showed a neck mass sizing about 50 x 25 mm. He began a new antibiotic therapy with Ceftriaxone intra muscle, with no modifications of the lesion. Few days later his clinical conditions drastically got worse - increasing pain and skin fistulization. So he practiced a MRI of the neck that showed a massive suppurated lesion of the neck. The patient was hospitalized in our Otolaryngology Unit where he began a diagnostic iter in order to clarify the nature of the lesion and differentiate between neoplastic/lymphoproliferative lesion and an infective one. After a biopsy of the lesion, the hysthopatologic examination reported the presence of dense mononuclear cell infiltrate surrounding a set of Langerhans cells, so our diagnostic suspect was addressed to extrapulmonary tuberculosis. The authors report a case of a healthy man without risk factors for tuberculosis infection, come to our attention with a large and aggressive unilateral tubercular cervical lymphadenitis, skin fistulization and no systemic symptoms. To make diagnosis of tubercular lymphadenitis, we sustain that biopsy is still the gold standard if FNAC is doubt.</p> 2019-08-30T15:19:51+02:00 ##submission.copyrightStatement## https://www.pagepressjournals.org/index.php/tmr/article/view/8145 West Nile virus: an overview of current information 2019-06-18T09:56:44+02:00 Annalisa Chianese annalisa.chianese1991@gmail.com Debora Stelitano deborastelitano@hotmail.it Roberta Astorri roberta.astorri@hotmail.it Enrica Serretiello enricaserritiello@libero.it Maria Teresa Della Rocca mtdellarocca@gmail.com Colombina Melardo colombina.melardo@gmail.com Mariateresa Vitiello mteresa.vitiello@gmail.com Marilena Galdiero marilena.galdiero@unicampania.it Gianluigi Franci gianluigi.franci@unicampania.it <p>West Nile Virus (WNV) is a vector-borne flavivirus primarily infecting mosquitoes, birds, horses and humans. WNV is responsible for asymptomatic infections or a variety of clinical manifestations ranging from mild febrile illness to neuroinvasive disease. The frequency and severity of WNV-related disease have lately increased in the European Union and in the neighbouring countries, with particular concern for the Mediterranean area. This trend is probably connected to a raise in both average temperatures and rainfall, favourable factors for WNV spread. Due to the marked and expanding geographical distribution of the vector and the high endemic potential of WNV, this virus is worldwide considered an increasing public health apprehension. An augmented burden of WNV severe illness has been reported. Alarmingly, no vaccine or specific antiviral treatments are currently available for WNV infection. Hereafter, we will review the available information summarizing molecular biology, pathogenesis, clinical manifestations, epidemiology, diagnosis and therapy for WNV infection in humans.</p> 2019-06-18T09:56:43+02:00 ##submission.copyrightStatement## https://www.pagepressjournals.org/index.php/tmr/article/view/8156 Chikungunya virus: Update on molecular biology, epidemiology and current strategies 2019-06-20T09:19:16+02:00 Debora Stelitano deborastelitano@hotmail.it Annalisa Chianese annalisa.chianese1991@gmail.com Roberta Astorri roberta.astorri@hotmail.com Enrica Serretiello enricaserretiello@libero.it Carla Zannella carla.zannella@unicampania.it Veronica Folliero veronica.folliero@unicampania.it Marilena Galdiero marilena.galdiero@unicampania.it Gianluigi Franci gianluigi.franci@unicampania.it Valeria Crudele valeriacrudele@gmail.com Mariateresa Vitiello mteresa.vitiello@gmail.com <p>Chikungunya virus (CHIKV), an arthropod-borne virus, is the aetiological agent of a disease characterized by several aspecific symptoms including fever, myalgia and arthralgia. The virus is primarily transmitted to humans through the bite of an infected mosquito of <em>Aedes</em> genus. This virus was first isolated in Tanzania in 1953, from which it spread to other African countries, Asia, Northern and Southern America, Europe and Oceania. Today, many human cases of CHIKV infection have been identified. The diffusion of CHIKV across the world, including Italy, is due to multiple factors amongst which the wide distribution of its vectors and high transmission efficiency play a crucial role. Currently, there are no specific treatments and effective vaccines against CHIKV; indeed, available therapies allow symptoms mitigation and some promising vaccines are undergoing clinical trials. The purpose of this review is to offer an updated picture of CHIKV molecular biology, epidemiology and vector distribution, clinical features and strategies for infection prevention and treatment.</p> 2019-06-20T00:00:00+02:00 ##submission.copyrightStatement## https://www.pagepressjournals.org/index.php/tmr/article/view/8142 Antibacterial and antiviral potential of neuropeptides 2019-06-14T09:06:44+02:00 Carla Zannella carla.zannella@unicampania.it Debora Stelitano deborastelitano@hotmail.it Veronica Folliero follieroveronica@libero.it Luciana Palomba luciana.palomba@gmail.com Tiziana Francesca Bovier francescabovier@gmail.com Roberta Astorri Kalendaegreche@hotmail.it Annalisa Chianese annalisa.chianese1991@gmail.com Marcellino Monda marcellino.monda@unicampania.it Marilena Galdiero marilena.galdiero@unicampania.it Gianluigi Franci gianluigi.franci@unicampania.it <p>The emergence of multidrug resistant bacteria is a global health threat and the discovery of new antimicrobial agents is an absolute priority. In this context endogenous peptides are emerging as novel potential candidates. In this work, we assessed the antimicrobial effects of orexins and ghrelin neuropeptides against gram-negative (<em>Escherichia coli</em>, <em>Salmonella typhimurium</em>, <em>Klebsiella pneumoniae</em>) and gram-positive (<em>Staphylococcus aureus</em>) bacteria. Orexin-B and ghrelin showed a potent bactericidal effect at concentration equal to or greater than 25 μg/ml. No antimicrobial activity has been observed for orexin-A. Furthermore, we investigated the antiviral proprieties of the three peptides against <em>herpes simplex</em> virus 1 (HSV-1). We found that orexin-B, but not orexin-A is effective for HSV-1 infectivity inhibition.</p> 2019-05-13T15:47:40+02:00 ##submission.copyrightStatement## https://www.pagepressjournals.org/index.php/tmr/article/view/8146 Airborne microbial flora in buffalo farms in a Mediterranean climate 2019-06-14T09:06:43+02:00 Debora Stelitano deborastelitano@hotmail.it Giuseppe Squillaci giuseppe.squillaci@ibaf.cnr.it Biagio Santella bi.santella@gmail.com Annalisa Chianese annalisa.chianese1991@gmail.com Virginia D'Oriano virginia.doriano@alice.it Emiliana Finamore emiliana.finamore@gmail.com Mariateresa Vitiello mteresa.vitiello@gmail.com Federica Maria Di Lella federicamariadilella@gmail.com Marilena Galdiero gianluigi.franci@unicampania.it Gianluigi Franci gianluigi.franci@unicampania.it <p>The last few decades have seen an increase in intensive buffalo farms worldwide. Such industrialized activity entails human and animal potential health-related hazards as well as for the environment. Given the breadth of the issue, in this study we focused on gathering microbiological air sampling in the Southern Italian buffalo farms in order to obtain further information on airborne microbial flora. In details, we evaluated the bio-aerosol concentration of cultivable bacteria and fungi in ten different buffalo farms. There are evidences showing that exposure to organic dust may exacerbate asthma, just as it may cause mucous membrane irritation and chronic bronchitis. Likewise, studies show that inhaling noninfectious microorganisms and their components may cause inflammation of the respiratory tract. As a result, this is a significant health hazard to these farms’ workers as well as to rural residents living closely to them.</p> 2019-05-27T17:11:57+02:00 ##submission.copyrightStatement##