Antibacterial and antiviral potential of neuropeptides

  • Carla Zannella Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Debora Stelitano Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Veronica Folliero Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Luciana Palomba Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Tiziana Francesca Bovier Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Roberta Astorri Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Annalisa Chianese Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Marcellino Monda Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Marilena Galdiero Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Gianluigi Franci | gianluigi.franci@unicampania.it Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.

Abstract

The emergence of multidrug resistant bacteria is a global health threat and the discovery of new antimicrobial agents is an absolute priority. In this context endogenous peptides are emerging as novel potential candidates. In this work, we assessed the antimicrobial effects of orexins and ghrelin neuropeptides against gram-negative (Escherichia coli, Salmonella typhimurium, Klebsiella pneumoniae) and gram-positive (Staphylococcus aureus) bacteria. Orexin-B and ghrelin showed a potent bactericidal effect at concentration equal to or greater than 25 μg/ml. No antimicrobial activity has been observed for orexin-A. Furthermore, we investigated the antiviral proprieties of the three peptides against herpes simplex virus 1 (HSV-1). We found that orexin-B, but not orexin-A is effective for HSV-1 infectivity inhibition.

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Published
2019-05-13
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Original Articles
Keywords:
Antibacterial, antiviral, neuropeptides, orexins, ghrelin
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How to Cite
Zannella, C., Stelitano, D., Folliero, V., Palomba, L., Bovier, T. F., Astorri, R., Chianese, A., Monda, M., Galdiero, M., & Franci, G. (2019). Antibacterial and antiviral potential of neuropeptides. Translational Medicine Reports, 3(1). https://doi.org/10.4081/tmr.8142

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