γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins

  • Nejat Akar | akar@medicine.ankara.edu.tr Department of Pediatric Molecular Genetics, Ankara University, Ankara, Turkey.
  • Kadir Sipahi Department of Pediatric Molecular Genetics, Ankara University, Ankara, Turkey.
  • Ece Akar Department of Pediatric Molecular Genetics, Ankara University, Ankara, Turkey.
  • Erkan Yilmaz Department of Pediatric Molecular Genetics, Ankara University, Ankara, Turkey.

Abstract

Aim of this study was to analyze γ A gene repeat polymorphism for the analysis of haplotypes of hemoglobin (Hb) variants such as Hb S, Hb D-Punjab, Hb O-Arab. Sickle cell cases had mainly Benin and Arab/Indian haplotype. We found three different haplotypes among Hb S, Hb O Arab and Hb D-Punjab cases. We named these three variants as Anatolian-1 and Anatolian-2 and Asian. Our data revealed that Hb O Arab may arise twice one from Asia and the other from Europe.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2014-09-29
Keywords:
hemoglobin, sickle cell disease, hemoglobin D-Punjab, repetitive sequence, Hb OArab, haplotype.
Statistics
  • Abstract views: 847

  • PDF: 729
  • HTML: 356
How to Cite
Akar, N., Sipahi, K., Akar, E., & Yilmaz, E. (2014). γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins. Thalassemia Reports, 4(2). https://doi.org/10.4081/thal.2014.1935