HbA2 measurements in β-thalassemia and in other conditions

  • Giovanni Ivaldi Laboratorio di Genetica Umana, Settore Microcitemia, Ospedali Galliera, Genova, Italy.
  • Giuseppina Barberio Medicina di Laboratorio, Ospedale di Treviso, Azienda U.L.S.S. N.9, Treviso, Italy.
  • Cornelis L. Harteveld The Hemoglobinopathies Laboratory, Departments of Human and Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands.
  • Piero Giordano | P.C.Giordano@lumc.nl The Hemoglobinopathies Laboratory, Departments of Human and Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands.

Abstract

Quite a few papers have been written on the significance of elevated hemoglobin (Hb) A2 as a parameter for the diagnosis of β-thalassemia trait, on the cutoff values to be used in diagnostics and on the significance and effects of factors reducing or elevating the expression of HbA2 and last but not least on the need for reliable measurement methods and precise calibrations with accurate standards. However, little has been published on the causes that elevate or reduce the HbA2 levels in β- and a-thalassemia and in other conditions. For a better understanding of the value of a precise measurement of this parameter we summarize and elucidate in this review the direct and indirect mechanisms that cause the variations in HbA2 expression and that influence the value of this parameter in particular conditions. We conclude by explaining the advantages and disadvantages of trusting on a precise measurement in the complete diagnostic contest.

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Author Biography

Piero Giordano, The Hemoglobinopathies Laboratory, Departments of Human and Clinical Genetics, Leiden University Medical Center, Leiden

Hemoglobinopathies Laboratory
Human and Clinical Genetics
Leiden University Medical Center
Leiden
Emeritus associated professor

Published
2014-09-29
Keywords:
hemoglobin A2, β-thalassemia.
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How to Cite
Ivaldi, G., Barberio, G., Harteveld, C. L., & Giordano, P. (2014). HbA2 measurements in β-thalassemia and in other conditions. Thalassemia Reports, 4(2). https://doi.org/10.4081/thal.2014.1832