Carotid intima-media thickness and oxidative stress markers for assessment of atherosclerosis in children with β thalassemia major

  • Geetanjali Jindal | geetanjali_jindal@yahoo.com Department of Pediatrics, Government Medical College and Hospital, Chandigarh, India.
  • Prashant Chavan Department of Pediatrics, Government Medical College and Hospital, Chandigarh, India.
  • Ravinder Kaur Department of Radiodiagnosis, Government Medical College and Hospital, Chandigarh, India.
  • Shivani Jaswal Department of Biochemistry, Government Medical College and Hospital, Chandigarh, India.
  • Kamal Kumar Singhal Department of Pediatrics, Government Medical College and Hospital, Chandigarh, India.
  • Anshu Palta Department of Pathology, Government Medical College and Hospital, Chandigarh, India.
  • Vishal Guglani Department of Pediatrics, Government Medical College and Hospital, Chandigarh, India.

Abstract

The present study evaluates carotid intimamedia thickness (CIMT) in children with β thalassemia major to assess atherosclerosis and its relation to the underlying proposed causative mechanisms via lipid peroxidation product malondialdehyde (MDA), oxidized lowdensity lipoproteins (LDL), total antioxidant level, and lipid profile. A cross sectional study was conducted on 62 children (31 cases and 31 controls). CIMT by high resolution ultrasound and biochemical parameters i.e., total cholesterol, triglycerides, high-density lipoproteins, LDL, Oxidized LDL, lipoprotein (a), lipid peroxidation product MDA and total antioxidant were measured in enrolled subjects and compared. In our study, CIMT was significantly increased in β thalassemia major patients’ as compared to healthy controls. Mean CIMT in cases was 0.69±0.11 mm and in controls 0.51±0.07 mm. Mean oxidized LDL (EU/mL) in cases 39.3±34.4 (range 14.4 to 160) was significantly raised (P=0.02, t test) as compared to controls 23.9±13.4 (range 12 to 70). In our study we found MDA levels (nmol/mL) to be increased in β thalassemia patients as compared to controls. Mean MDA was 10.0±3.27 (4.41 to 17.48) in cases while in controls was 6.87±4.55 (1.5 to 17.9). Our study results show CIMT as an early marker of atherogenesis in β thalassemia major. Oxidative stress markers are also increased in β thalassemia major patients and lipoprotein (a) shows a positive correlation with CIMT. The present study points towards various atherogenetic mechanisms in β thalassemia major.

 

本研究评价β重型地中海贫血患儿颈动脉内膜中层厚度(CIMT),以评估动脉粥样硬化,以及与潜在通过血脂过氧化反应产物丙二醛(MDA)、氧化低密度脂蛋白(LDL)、总抗氧化水平和血脂谱所提出致病机制之间的关系。 在62名儿童(31例病例和31例对照)中进行了一项横断面研究。 在入组受试者中通过高分辨率超声和生化指标(即总胆固醇、甘油三酯、高密度脂蛋白、LDL、氧化LDL,脂蛋白(a)、血脂过氧化产物MDA和总抗氧化剂)测量CIMT并进行比较。 在我们的研究中,CIMT在β重型地中海贫血患者中比健康对照组显著增加。 病例组中的平均CIMT为0.69±0.11 mm,对照组0.51±0.07 mm。病例组中平均氧化LDL(EU/mL)为39.3±34.4(从14.4到160的范围)与对照组的23.9±13.4(12至70的范围)相比显著升高(P = 0.02,t检验)。 在我们的研究中,我们发现β地中海贫血患者中的MDA水平(nmol/mL)比对照组更高。 病例组中的平均MDA为10.0±3.27(4.41至17.48),而对照组为6.87±4.55(1.5到17.9)。 我们的研究结果表明,CIMT是β重型地中海贫血动脉粥样硬化的早期标记物。 氧化应激标记物在β重型地中海贫血患者中也有增加,脂蛋白(a)显示出与CIMT呈正相关。 本研究针对β重型地中海贫血中的各种动脉粥样硬化机制。

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2016-05-06
Info
Issue
Section
Original Articles
Supporting Agencies
nil
Keywords:
β thalassemia major, carotid intimamedia thickness, oxidative stress markers, atherosclerosis.
Statistics
  • Abstract views: 1384

  • PDF: 627
  • HTML: 675
How to Cite
Jindal, G., Chavan, P., Kaur, R., Jaswal, S., Singhal, K., Palta, A., & Guglani, V. (2016). Carotid intima-media thickness and oxidative stress markers for assessment of atherosclerosis in children with β thalassemia major. Thalassemia Reports, 6(1). https://doi.org/10.4081/thal.2016.4939