Raman spectroscopy technology to monitor the carotenoids in skin of thalassemia patients: a novel non-invasive tool relating oxidative stress with iron burden

  • Anna Perrone Dipartimento STEBICEF, Università di Palermo, Italy.
  • Luisa Tesoriere Dipartimento STEBICEF, Università di Palermo, Italy.
  • Anna Maria Pintaudi Dipartimento STEBICEF, Università di Palermo, Italy.
  • Alessandro Attanzio Dipartimento STEBICEF, Università di Palermo, Italy.
  • Paolo Rigano Divisione di Ematologia e Malattie rare del sangue e degli organi ematopoietici, Ospedali Riuniti Villa Sofia Cervello, Palermo, Italy.
  • Aurelio Maggio Dipartimento STEBICEF, Università di Palermo, Italy.
  • Maria Antonietta Livrea | maria.livrea@unipa.it Dipartimento STEBICEF, Università di Palermo, Italy.

Abstract

In this work we approach the relationship between redox state and iron overload by noninvasive instrumental techniques. Intracardiac, liver iron and liver fibrosis have been monitored in transfusion-dependent thalassemia patients by magnetic resonance imaging and hepatic transient elastography examinations. These measurements have been matched with a non-invasive, and yet unexplored in clinical practice, evaluation of body’s oxidative stress through measurement of antioxidant carotenoids in skin, by a spectroscopic method based on Raman technology (RRS). The global body’s antioxidant status results from a balance between the level of antioxidants in cells and body fluids, including blood, and pro-oxidant species endogenously produced or coming from external sources. On this basis, the level of skin carotenoids can be considered a biomarker of the entire antioxidant status. In our work the use of RRS method provided information on the redox state of thalassemia patients, which was correlated with the iron status of the patients. Due to the highly adverse effects of accumulated iron, the novel, simple, non-invasive RRS to monitor dermal carotenoids with high compliance of the patients may be a useful tool for the management of thalassemia patients.

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Published
2014-09-29
Keywords:
Raman spectroscopy technology, skin carotenoids, thalassemia, oxidative stress.
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How to Cite
Perrone, A., Tesoriere, L., Pintaudi, A. M., Attanzio, A., Rigano, P., Maggio, A., & Livrea, M. A. (2014). Raman spectroscopy technology to monitor the carotenoids in skin of thalassemia patients: a novel non-invasive tool relating oxidative stress with iron burden. Thalassemia Reports, 4(2). https://doi.org/10.4081/thal.2014.1967