Preimplantation HLA typing for stem cell transplantation treatment of hemoglobinopathies

  • Anver Kuliev | anverkuliev@hotmail.com Reproductive Genetics Institute, Chicago IL, United States.
  • Oleg Verlinsky Reproductive Genetics Institute, Chicago IL, United States.
  • Svetlana Rechitsky Reproductive Genetics Institute, Chicago IL, United States.

Abstract

Preimplantation genetic diagnosis (PGD) for HLA typing is steadily becoming an option for at risk couples with thalassemic children, requiring HLA matched bone marrow transplantation treatment. The paper presents the world’s largest PGD experience of 475 cases for over 2 dozens thalassemia mutations, resulting in birth of 132 unaffected children. A total of 146 cases were performed together with preimplantation HLA typing, resulting in detection and transfer of HLA matched unaffected embryos in 83 of them, yielding the birth of 16 HLA matched children, potential donors for their affected siblings. The presented experience of HLA matched stem cell transplantation for thalassemia, following PGD demonstrated a successful hematopoietic reconstitution both for younger and older patients. The data show that PGD is an efficient approach for HLA matched stem cell transplantation treatment for thalassemia.

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Published
2014-09-29
Keywords:
preimplantation genetic diagnosis for hemoglobinopathies, preimplantation HLA typing, stem cell transplantation.
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How to Cite
Kuliev, A., Verlinsky, O., & Rechitsky, S. (2014). Preimplantation HLA typing for stem cell transplantation treatment of hemoglobinopathies. Thalassemia Reports, 4(2). https://doi.org/10.4081/thal.2014.1853