Ozone Therapy 2019-05-13T17:28:35+02:00 Francesca Baccino Open Journal Systems <p><strong>Ozone Therapy</strong> intends to be the accessible and innovative leading edge interdisciplinary journal for the ozone-therapy practitioners worldwide, by publishing in different languages to be easier referred to and by establishing its own source of scientific information. <strong>Ozone Therapy</strong> seeks to publish peer-reviewed, original manuscripts dedicated to oxygen-ozone therapy; innovative observational works to open new therapeutic frontiers and study/verification scientific papers regarding known and registered applications;&nbsp;interdisciplinary papers devoted to other disciplines (e.g. Management, Finance, Healthcare) connected with the use of ozone in different fields.</p> <p>This journal does not apply the article processing charge to Authors as it is supported by institutional funds.</p> <p><strong>Ozone Therapy</strong>&nbsp;is published under the auspices of the SIOOT (Italian Society for Oxygen-Ozone Therapy).</p> Outpatient evaluation of oxidative stress in subjects undergoing systemic oxygen-ozone therapy 2019-05-13T17:28:35+02:00 Fortunato Loprete Francesco Vaiano Luigi Valdenassi <p>Oxygen-ozone therapy improves the quality of life in patients affected by various diseases. The purpose of this study was to verify and eventually quantify the production of free radicals generated by oxidative stress induced by the ozonated auto-hemoinfusion in subjects subjected to this practice and eventually evaluate and naturally quantify the plasma antioxidant power of the subjects under examination. All subjects showed a significant improvement in the oxidative balance already at the first check, which was maintained (albeit with a minimal non-significant loss) at the end of the study. The results of the study have made it possible to verify that systemic ozonated auto-hemoinfusion not only does not involve further oxidative stress but even exerts an important antioxidant effect, through the scavenger effect of free radicals.</p> 2019-04-11T13:58:30+02:00 ##submission.copyrightStatement## Oxygen-ozone therapy in arthroplasty infections 2019-05-13T17:28:34+02:00 Alessandra Vittoria De Lisi Marianno Franzini Giovanni Ricevuti <p>The prevention of surgical site infections is a priority within the objectives of the National Health System. The negative consequences of postoperative infections (morbidity, duration of hospitalization, mortality) are particularly serious events for the individual patient and for the community, given both the welfare resources needed to treat them, and the continued growth of the phenomenon of antibiotic resistance. In a global health context in which evidence-based medicine has established itself, all medical interventions must be reconsidered in the light of what can be inferred from the literature evaluated according to strict methodological criteria, all the more so when the evidence is available and unanimously shared. The future objective will be to introduce in the national guidelines a protocol involving the use of ozone therapy alongside antibiotic therapy, both in the prevention and treatment of infections, to avoid the emergence of antibiotic resistance and thus reduce the expenditure of the national health system.</p> 2019-04-11T14:03:03+02:00 ##submission.copyrightStatement## Use of ozone in water, agriculture and zootechnics: relationships between dysbiosis and mental disorders 2019-05-13T17:28:33+02:00 Giuseppe Vitali Luigi Valdenassi <p>Ozone (O<sub>3</sub>) is a bluish-coloured gas with a characteristic odour that forms in the layers of the atmosphere, near electric shocks, sparks or lightning; the extremely high voltages reached during thunderstorms produce ozone from oxygen. The particular <em>fresh</em>, <em>clean odour</em>, <em>the smell of spring rain</em> is the result of the ozone reproduced by nature. Ozone comes from the Greek word <em>ozein</em>, which means <em>to sense the odour of</em>. Ozone is an essential gas for life on Earth, allowing the absorption of ultraviolet light emanating from the Sun; in fact, the ozone layer in the stratosphere protects against the harmful action of UV-B ultraviolet rays. The gas, not being stable over the long term, is therefore not produced in cylinders; it can currently be prepared through special, certified and authorised devices, which use small electric discharges to convert the oxygen into ozone. It is a molecule formed by three oxygen atoms (O<sub>3</sub>), with a negative electric charge. It has a short half-life, and will therefore decay after a certain time back to its original form: oxygen. Essentially ozone is nothing but oxygen (O<sub>2</sub>) with an extra oxygen atom, which has a high electrical charge. Ozone works according to the principle of oxidation. The oxidation mechanism follows two paths: i) Direct: contact of the molecule with the contaminant; ii) Indirect: the ozone decomposes into hydroxyl radicals, more powerful but short-lived. Both reactions occur simultaneously. When the static charged ozone molecule (O<sub>3</sub>) comes into contact with something <em>capable of oxidising</em>, the ozone molecule’s charge flows directly over it. This happens because ozone is very unstable and tends to change back into its original form (O<sub>2</sub>). Ozone can oxidise with all kinds of materials, but also with odours and microorganisms such as bacteria, viruses and fungi. The supplemental oxygen atom is released from the ozone molecule and binds to the other material. In the end, only the pure and stable oxygen molecule remains. Ozone is one of the strongest oxidation techniques available for oxidising solutes. The supplemental/added oxygen atom will bind (=oxidation) in a second to each component that comes into contact with ozone. It is used for a wide range of purification processes. It can be employed for disinfection in municipal wastewater and in drinking water treatment plants. However, ozone is increasingly used in the industrial sector. In the food industry, for example, it is used for disinfection, and in the textile and paper industry it is used to oxidise wastewater. The main benefit of ozone is its clean nature, because it only oxidises the materials, barely forming any by-products. Since ozone has a strong characteristic distinctive odour, even very low concentrations can be quickly perceived. This generally makes it safe to work with. Since Chlorine is still the best-known oxidising and disinfectant agent, ozone is often compared with chlorine. Unlike chlorine, antibiotics or various chlorine derivatives that have no effect, ozone acts on viruses and spores. In its sterilising action, ozone directly attacks bacteria by inducing a catalytic oxidation process on the mass of bacterial proteins, unlike chlorine which acts only through specific enzymatic poisoning of vital centres, a process which requires a longer time interval and sensitive quantity for its diffusion inside the cytoplasm. Regarding the virucidal action, it is interesting to keep in mind that with a residual ozone rate of 0.6 ppm (parts per million) and with a contact time of 2 minutes, the percentage of inactivation for bacteria and viruses present in the disinfection liquid is total. Ozone’s oxidising power is 120 times greater than that of chlorine.</p> 2019-04-11T14:31:28+02:00 ##submission.copyrightStatement## Oxygen-ozone therapy in meningoencephalitis and chronic fatigue syndrome. Treatment in the field of competitive sports: case report 2019-05-13T17:28:31+02:00 Luca Morelli Simona Carla Bramani Federico Carlo Morelli <p>Our study was born from the observation of a clinical case of a boy who arrived in the Emergency Room of our hospital for persistent hyperpyrexia, headache and prolonged emetic episodes and complaining of objective photophobia and dizziness. The patient underwent haematochemical tests, chemical-physical examination of Chronic Fatigue Syndrome (CFS), negative for bacteria, negative for <em>Neisseria Meningitidis</em>, <em>Escherichia Coli</em> <em>121</em>, <em>Haemophilus Influenzae</em>, <em>Stafilococcus Pneumoniae</em>, <em>Stafilococcus Agalactiae</em> and with slightly positive reaction to Pandy’s test; he was subjected to neurological examination, to Nuclear Magnetic Resonance of the brain and encephalic trunk with contrast agent which resulted negative, and to EEG that showed a slightly slowed-down brain electrical activity, in right occipital region, and frontal irritative abnormalities. Given these clinical and instrumental investigations, an acute meningoencephalitis was diagnosed. During his hospitalization, the patient was treated with intravenous antibiotic therapy and intravenous antiviral therapy for 12 days. At discharge, in the absence of specific therapy, and considering the protraction of the cephalic, dizzying, asthenic and myalgic symptoms and in relation to hematochemical and serological tests (positive for antibodies to Herpes 1 IgG), Epstein Barr Virus antibodies (positive for Viral Capsid Antigen IgG and IgGE BNA, for Extractable Nuclear Antigen and IgG Cytomegalovirus) he was diagnosed a Post-infectious CFS. The patient was treated with Oxygen Ozone Rectal Insufflative Therapy on a bi-weekly basis for 4 weeks, associated with Micetrin, a dietary supplement with sweetener based on Vitamin C, Shitake, Reishi, Maitake, Cordyceps, Magnesium and SOD, continued the treatment on a weekly basis for a further 4 weeks until the complete remission of the symptoms of asthenic, neurological and clinical parameters.</p> 2019-04-11T14:38:13+02:00 ##submission.copyrightStatement##