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The terms chronic fatigue syndrome and myalgic encephalomyelitis describe a complex physical illness characterized by debilitating fatigue, post-exertional malaise, pain, cognitive problems, sleep dysfunction and an array of other immune, neurological and autonomic symptoms. At the MEDE Clinic of Sacile, Italy, from February 2016 to December 2017, we have treated 65 patients, with auto hemo transfusion, according to the Scientific Society of Oxygen Ozone Therapy (SIOOT) protocols, twice a week for one month and twice a month as maintenance therapy. In conclusion, at our knowledge this is the largest study of patients with chronic fatigue syndrome treated with ozone therapy. Oxygen ozone therapy is an effective therapy in the treatment of chronic fatigue syndrome. However, more patients are needed and in particular a longer follow up is a necessary. In the meantime, ozone therapy seems a treatment that, also because without any side effect, is possible to be proposed to patients with chronic fatigue syndrome that are not obtaining sufficient results from available therapy.
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