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Oxygen-ozone therapy is effective for both activation of the cerebral microcirculation and increasing energy production by neurons, as recent studies have shown. As well as this, it has been shown to have a proven anti-inflammatory and antispasmodic action, improve microcirculation, increase the production of cellular energy, activate the mitochondrial antioxidant system and facilitate the elimination of cell catabolites. It also seems that oxygen-ozone therapy improves and prolong the effects of drugs such as Levodopa, Selegiline and Bromocriptine and antioxidants, therefore these activities could help us understand the improvements recorded in Parkinson’s patients treated with oxygen-ozone therapy. The aim of our work was to carry out a postural, stabilometric and symptomatological assessment of the effects of oxygen-ozone therapy by using rectal insufflation in patients who undertook the intense motor activity of non-contact boxing. The results showed a significant reduction in the myofunctional, postural and stabilometric symptoms of Parkinsonian patients who practiced non-contact boxing activities, implemented though systemic oxygen-ozone therapy with insufflation.