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The panniculosis or edematous fibrosclerotic panniculopathy (PEFS), commonly called cellulite is a subcutaneous adipose disease that afflicts the vast majority of women at all ages. PEFS is framed as a subcutaneous adipose suffering from venous and lymphatic stasis whose etiology is multifactorial. Many others are the implications and clinical relapses of diseases of inflammatory or autoimmune basis that determine disease states with involvement of the patient’s general conditions. The oxygen-ozone therapy, thanks to its abilities of improving the rheological properties of the microcirculation, immuno-modulating and anti-inflammatory abnormalities, arises as adjuvant and is a valid method, which is also an alternative compared to conventional protocols.
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