Oxygen-ozone therapy: paradoxical stimulation of ozone

  • Luigi Valdenassi | luigi.valdenassi@unipv.it Oxygen-Ozone Therapy Scientific Society, Gorle (BG); Department of Internal Medicine and Medical Therapy, University of Pavia, Italy.
  • Marianno Franzini Oxygen-Ozone Therapy Scientific Society, Gorle (BG), Italy.
  • Vincenzo Simonetti Oxygen-Ozone Therapy Scientific Society, Gorle (BG); Kaos non-profit Association, Caselle Torinese (TO), Italy.
  • Giovanni Ricevuti Department of Internal Medicine, University of Pavia, Italy.


After several years of scientific research and accurate clinical practice, the oxygen-ozone therapy continues to represent a method full of prospects and new opportunities. On this basis we present an updated review on basic mechanisms through which the ozone acts. Ozone, a molecule notable for its heterodoxy and atypicalness, has been regarded with suspicious for a long time since it was a possible generator of free radicals and correlated pathologies, but it is important distinguishing between the oxidative damage from free radicals, characterized by irreversible chemical modifications of the molecular target, and the physiological effects from free radicals (redox signaling), characterized on the other hand, by reversible chemical and selective alterations, which are potentially suitable to become an active part in the various metabolic regulation mechanisms, with positive effects on several pathologies.



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Oxygen-ozone therapy, free radicals, redox signaling.
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How to Cite
Valdenassi, L., Franzini, M., Simonetti, V., & Ricevuti, G. (2016). Oxygen-ozone therapy: paradoxical stimulation of ozone. Ozone Therapy, 1(1), 2-4. https://doi.org/10.4081/ozone.2016.5837