Microbiologia Medica 2019-05-23T17:31:13+02:00 Emanuela Fusinato Open Journal Systems <p><strong>Microbiologia Medica</strong> (MM) is the official publication of the Italian Association of Clinical Microbiologists (AMCLI). It publishes peer-reviewed papers that present basic and applied research relevant to therapy and diagnostics in the fields of: bacteriology, mycology, virology, parasitology, mycobacteriology, infectious diseases, chemotherapy, antimicrobial agents, immunology, autoimmunity and epidemiology.&nbsp; The journal publishes <em>Editorials, Reviews, Original Articles, Clinical Cases, Short Communications</em> and <em>Letters to the Editor</em>.&nbsp; MM is devoted to the diffusion of any progress related to all aspects of clinical microbiology. Reports about new techniques, methods and processes dealing with quality control procedures are also considered. Papers on isolation, identification and epidemiology of microorganisms as index of nosocomial infections, or reports on microorganisms collected from animals and environment as vehicles of antibiotic resistant strains are also welcome.</p> <p>The journal is completely free (there are no charges for submission and/or publication), since it it supported by institutional funds and provides immediate Open Access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.</p> <p><strong><a href="/index.php/mm/about/submissions">Submit your paper to our journal!</a></strong></p> The journal I would like 2019-05-23T17:31:09+02:00 Ersilia Vita Fiscarelli <p>Not available</p> 2019-05-22T15:27:56+02:00 ##submission.copyrightStatement## The global Mycobacterium chimaera outbreak 2019-05-23T17:31:11+02:00 Enrico Tortoli <p>Infections due to <em>Mycobacterium chimaera</em> associated with a heater-cooler device used during the open-heart surgery have been reported worldwide. These cases represent the first outbreak caused by a non-tuberculous mycobacterium at a global level. Salient features of the infection are long latency and high mortality. Different aspects of the <em>M. chimaera</em> outbreak, from the first detected cases to the present burden are reviewed in this study. Although the source has been found and thwarted, new cases continue to be detected due to the late manifestation of symptomatology. The treatment remains poorly effective and mortality is around 50%.</p> 2019-05-22T13:01:20+02:00 ##submission.copyrightStatement## Atopobium vaginae: a literature review, on findings and potential clinical implications 2019-05-23T17:31:09+02:00 Andrea Mariano Angelo Salzo Valentina Felice Massimiliano Scutellà <p><em>Atopobium vaginaeis</em> an anaerobic Gram-positive bacterium. It is recognized as a causal agent of bacterial vaginosis onset and occasionally associated to gynaecologic-obstetric complications (including pelvic inflammatory disease, endometritis, tubo-ovarian abscesses and preterm delivery with neonatal consequences). Additionally, bacteraemia and invasive infections have rarely been reported. The scientific and technological progress allowed an accurate and rapid identification of <em>Atopobium vaginae</em> supporting diagnosis and clinic interventions. In this article, literature has been deeply examined to report the state-of-the-art on <em>Atopobium vaginae</em>, which might be useful in clinical scenarios.</p> 2019-05-22T13:11:37+02:00 ##submission.copyrightStatement## Recurrence of measles in central Italy: the experience of a hospital in Rome 2019-05-23T17:31:12+02:00 Andrea Petrucca Antonella Alari Styliani Papadopoulou Crisitina Petrucci Iolanda Santino <p>Measles continue to be a major public health issue worldwide with high morbidity and mortality rates. The disease is still endemic in Europe and during 2017 a vast outbreak was described in Italy, Romania and Hungary, which led to thousands of new cases and several deaths. In Italy, 3931 confirmed cases of measles were reported to the Italian national surveillance system from many Italian administrative regions; Lazio, in central Italy, exhibited the highest number of infected patients 1322 (33.63%) and as well as the highest incidence. In this study, we describe the results of a retrospective analysis, carried out during 2016 and 2017, concerning the measles antibody prevalence in patients and healthcare workers attending the Sant’Andrea Hospital of Rome (Lazio). A total of 94 patients (median 30 years of age) were screened in 2016, and 316 (median 40 years of age) during 2017, with an increase of 236% compared to previous year. During 2017, 41 confirmed cases of measles were reported while none in 2016 (P&lt;0.007), and we found a suboptimal immunization coverage in our cohort of patients. Furthermore, measles surveillance of Sant’Andrea healthcare workers during the study period involved 208 personnel units (median &gt;47 years of age) and only one confirmed measles infection was recorded in 2017. These results suggest that there is still an unvaccinated portion of the adult population, who sustain the endemic circulation of measles in Italy. In addition to reach herd immunization on children of 2 years old, catch-up vaccination campaign targeting adult population in Italy and other European countries needs to be implemented to prevent future measles outbreak.</p> 2019-05-22T12:57:55+02:00 ##submission.copyrightStatement## Frequency and antibiotic susceptibility pattern of uropathogenic agents of urinary tract infections among asymptomatic diabetic patients in Okada community, southern Nigeria 2019-05-23T17:31:10+02:00 Ruqayyah B. Adegbite Hammed O. Ojokuku Kamoru A. Adedokun Musiliu A. Oyenike Ramat T. Kamorudeen <p>Massive evidence showed that patients with diabetes have a high risk of urinary tract infections. We studied the frequency of potential urinary uropathogens among diabetic patients and identified their antimicrobial susceptibility patterns. This was a prospective hospital-based study conducted at the Department of Medical Laboratory Science, Igbinedion University Teaching Hospital, Southern Nigeria, between January 2014 and May, 2014. We included 240 previously confirmed diabetic patients (women, n=70 and men, n=170) who were regularly followed up without prior treatment with any antimicrobial therapy and within the age range of 26-75 years. Patient personal history data and midstream urine samples were collected. Urine samples were processed in the laboratory following a Standard Laboratory Protocol. <em>Escherichia coli</em>, <em>Staphylococcus aureus</em>, <em>Klebsiella</em> spp. and <em>Candida</em> spp. were isolated in this study. A significant bacteriuria count was estimated in 12.5% of the sampled population, while 17.1 and 10.6% were estimated in females and males, respectively. Similarly, candiduria was found in female, male and total sample in 12.9%, 2.9%, and 5.8%, in that order. According to antimicrobial sensitivity testing, the Gram-negative bacilli isolated were highly sensitive to nitrofurantoin followed by ofloxacin, gentamycin and least sensitive to cefuroxime. Estimation of potential uropathogens among asymptomatic diabetic populations may avert possible urinary tract infections and their possible complications ultimately and thus prevent possible advanced renal diseases.</p> 2019-05-22T13:06:47+02:00 ##submission.copyrightStatement## Colistin-resistant microorganisms and cystic fibrosis: microbiological surveillance in an Italian Children’s Hospital 2019-05-23T17:31:08+02:00 Anna Lisa Montemari Vanessa Tuccio Guarna Assanti Giulia Linardos Giovanni Di Bonaventura Gabriella Ricciotti Ersilia Vita Fiscarelli <p>Several advances in the medical field are often dependent on the ability to fight infections with the use of antibiotics, including joint replacements, organ transplants, and cancer therapy. The capacity of the bacteria to adapt to and escape from the mechanisms of action of antibiotics makes the antimicrobial resistance a serious public health problem worldwide. Polymyxin E colistin has rarely been used because of its nephrotoxicity and neurotoxicity. More recently, the emergence of multi-drug resistant bacteria as carbapenem-resistant <em>Klebsiella pneumoniae</em>, <em>Acinetobacter&nbsp;baumannii</em> and <em>Pseudomonas aeruginosa</em> and the re-evaluation of its pharmacokinetic properties have led to a resurgence of colistin as a treatment option, contributing to select resistant strains. Investigating the phenomenon of colistin-resistance in gram-negative bacteria, especially <em>P. aeruginosa</em>, is now mandatory, particularly after identification of a plasmid-mediated mechanism for the resistance to colistin (<em>mcr</em>) in <em>Enterobacteriaceae</em> strains, a mechanism transferable to other species. In this study, we investigated colistin-resistance in gram-negative bacteria isolated from respiratory secretions of cystic fibrosis patients in follow-up at Children’s Hospital Bambino Gesù of Rome.</p> 2019-05-22T15:36:24+02:00 ##submission.copyrightStatement## An unexpected case report of Ascaris lumbricoides in pregnant woman 2019-05-23T17:31:13+02:00 Valentino Granero Daniela Dompè Elvio Peyronel Cristina Crocillà Maria Rita Cavallo <p>Soil-transmitted helminths, primarily <em>Ascaris</em>, <em>Trichuris</em> and hookworm, infect more than 760 million people worldwide. Parasitic diseases represent a social and economic problem in developing countries. Herein, we present a case of ascariasis in a pregnant woman, who was treated with mebendazole for three days without teratogenic effects. It is emphasized the need not to underestimate helminth infections in developed countries and how rapid notification is needed in order to quickly establish a guided therapy especially in pregnant women.</p> 2019-05-22T12:44:25+02:00 ##submission.copyrightStatement##