@article{Stevan_Fusato_Armanini_Bertoloni_De Seta_Leli_Rassu_2017, title={In vitro effects of glycyrrhetinic acid and hyaluronic acid on the growth of vulvovaginal Candida albicans and other yeasts}, volume={32}, url={https://www.pagepressjournals.org/mm/article/view/6974}, DOI={10.4081/mm.2017.6974}, abstractNote={<em>Aims.</em> The present study aimed to test the <em>in vitro</em> activity against <em>Candida albicans</em> and non-<em>albicans</em> strains of 18-β glycyrrhetinic acid (18-β GA) and hyaluronic acid (HA), both alone and in combination. This antimicrobial activity was assessed using the National Committee for Clinical Laboratory Standards (NCCLS) method on <em>Candida</em> strains that were isolated from patients with recurrent vulvovaginal candidiasis (RVVC). <em><br />Results</em>. Our results demonstrate that the anti-<em>Candida</em> activity is independent from antifungal susceptibility level and the fact that the growth inhibition is stronger at acidic pH level makes the two drugs a promising biological alternative for the topical treatment of vulvovaginal candidiasis (VVC) and RVVC. <em><br />Conclusions</em>. Furthermore, the reduction of both budding cells formation and germ tube elongation, on mammalian cell monolayers, may explain the observed growth inhibition and suggest a decreased virulence, respectively.}, number={4}, journal={Microbiologia Medica}, author={Stevan, Martina and Fusato, Eleonora and Armanini, Decio and Bertoloni, Giulio and De Seta, Francesco and Leli, Christian and Rassu, Mario}, year={2017}, month={Dec.} }