Clinical utility of QuantiFERON TB Gold Test in the diagnosis of latent tuberculosis infections

  • Salvatore Nisticò | ivanpotente@libero.it
  • Giuseppe Ivan Potente
  • Maria Teresa Cerminara
  • Lavinia Scuro
  • Angela Luciano

Abstract

Introduction: Early diagnosis of latent tuberculosis infection can avoid a progression to active tuberculosis.The interferon gamma (IFN-γ) production measured by the new interferon-gamma release assays (IGRAs) can be used to identify subjects with, because the tuberculin skin test, is unreliable to discriminative between subjects with and others. Methods: 186 patients tested positive with the tuberculin skin test were evaluated with QuantiFERON- TB Gold [QFT-G (Cellestis Ltd, Carnegie, Australia)]. Results: 61 (32.8%) samples showed a positive response with QFT-G test and only 1 (0.54%) patient tested indeterminate. Conclusion: These preliminary data suggest that QFT-G-positivity showed a strong correlation with clinical suspect of latent tuberculosis infection.

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Published
2010-03-31
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Original Articles
Keywords:
tuberculosis, QuantiFERON-TB Gold, latent tuberculosis infection
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How to Cite
Nisticò, S., Potente, G., Cerminara, M. T., Scuro, L., & Luciano, A. (2010). Clinical utility of QuantiFERON TB Gold Test in the diagnosis of latent tuberculosis infections. Microbiologia Medica, 25(1). https://doi.org/10.4081/mm.2010.2473

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