Significance of the “isolated EBNA-1 IgG” pattern in past EBV infection


https://doi.org/10.4081/mm.2009.2553
Vol. 24 No. 1 (2009)
Submitted: 17 February 2014
Accepted: 17 February 2014
Published: 31 March 2009
immunoblotting, EBNA-1, EBV, mononucleosis, serological pattern
Abstract Views: 1466
PDF: 1092
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

The ELISA screening detection of anti-EBNA-1 IgG in the absence of VCA IgG and IgM is rare but may lead to doubts in interpretation.We used immunoblotting to characterise 23 serum samples with “isolated EBNA-1 IgG” upon ELISA screening, and found that all showed VCA anti-p23 and 13 (56.6%) also showed VCA anti-p18 antibodies. It therefore seems impossible for a sample to show anti-EBNA-1 IgG without anti-VCA IgG antibodies. Furthermore, although anti-p18 antibodies are thought to develop later and therefore considered to be markers of past infection, about 1% of all previously infected EBNA-1 IgG-positive patients do not have them.

De Paschale, M., Cagnin, D., Manco, M. T., & Clerici, P. (2009). Significance of the “isolated EBNA-1 IgG” pattern in past EBV infection. Microbiologia Medica, 24(1). https://doi.org/10.4081/mm.2009.2553

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC