Colistin-resistant microorganisms and cystic fibrosis: microbiological surveillance in an Italian Children’s Hospital

  • Anna Lisa Montemari Cystic Fibrosis Microbiology Laboratory, Department of Laboratories, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy.
  • Vanessa Tuccio Guarna Assanti Cystic Fibrosis Microbiology Laboratory, Department of Laboratories, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy.
  • Giulia Linardos Cystic Fibrosis Microbiology Laboratory, Department of Laboratories, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy.
  • Giovanni Di Bonaventura Department of Medical, Oral and Biotechnological Sciences; Centre of Excellence on Ageing and Translational Medicine, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy.
  • Gabriella Ricciotti Cystic Fibrosis Microbiology Laboratory, Department of Laboratories, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy.
  • Ersilia Vita Fiscarelli | evita.fiscarelli@opbg.net Cystic Fibrosis Microbiology Laboratory, Department of Laboratories, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy.

Abstract

Several advances in the medical field are often dependent on the ability to fight infections with the use of antibiotics, including joint replacements, organ transplants, and cancer therapy. The capacity of the bacteria to adapt to and escape from the mechanisms of action of antibiotics makes the antimicrobial resistance a serious public health problem worldwide. Polymyxin E colistin has rarely been used because of its nephrotoxicity and neurotoxicity. More recently, the emergence of multi-drug resistant bacteria as carbapenem-resistant Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa and the re-evaluation of its pharmacokinetic properties have led to a resurgence of colistin as a treatment option, contributing to select resistant strains. Investigating the phenomenon of colistin-resistance in gram-negative bacteria, especially P. aeruginosa, is now mandatory, particularly after identification of a plasmid-mediated mechanism for the resistance to colistin (mcr) in Enterobacteriaceae strains, a mechanism transferable to other species. In this study, we investigated colistin-resistance in gram-negative bacteria isolated from respiratory secretions of cystic fibrosis patients in follow-up at Children’s Hospital Bambino Gesù of Rome.

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Published
2019-05-22
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Original Articles
Keywords:
colistin-resistance, mcr-1, cystic fibrosis
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How to Cite
Montemari, A., Tuccio Guarna Assanti, V., Linardos, G., Di Bonaventura, G., Ricciotti, G., & Fiscarelli, E. (2019). Colistin-resistant microorganisms and cystic fibrosis: microbiological surveillance in an Italian Children’s Hospital. Microbiologia Medica, 34(1). https://doi.org/10.4081/mm.2019.8163