Current antimicrobial sensitivity pattern of typhoidal salmonellae in a referral diagnostic centre

  • Umer Shujat | umershujaat2144@gmail.com Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
  • Aamer Ikram Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
  • Inam Qadir Javaid Hashmi Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
  • Shahid Ahmed Abbasi Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
  • Amna Afzal Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
  • Muhammad Ayyub Armed Forces Institute of Pathology, Rawalpindi, Pakistan.

Abstract

Background: Infections caused by typhoidal salmonellae are an important public health concern in Pakistan. Inappropriate and injudicious use of fluoroquinolones has reduced their efficacy due to development of high level resistance.
Aim: To ascertain the current susceptibility pattern of typhoidal salmonellae thus guiding the physicians for better management of typhoid patients.
Materials and Methods: A study was conducted at our institution from January 2012 through December 2013 to investigate current susceptibility pattern of typhoidal salmonellae.
Results: Out of 200 isolates, 107 (53.5%) were identified as Salmonella Typhi and 93 (46.5%) as Salmonella Paratyphi A. Sensitivities of Salmonella Typhi were as follows: ampicillin (48.6%), chloramphenicol (45.8%), co-trimoxazole (40.1%), ciprofloxacin (11.2%). Sensitivities of Salmonella Paratyphi A were: ampicillin (80.6%), chloramphenicol (89.2%), co-trimoxazole (90.3%), and ciprofloxacin (16.1%). No resistance was detected against third generation cephalosporins.
Conclusions: Typhoidal salmonellae are still entirely susceptible to third generation cephalosporins in our setting. Marked rise in resistance to fluoroquinolones has reduced their empirical usage. Sensitivity of Salmonella Paratyphi A to conventional antityphoid drugs was encouraging.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2016-03-31
Info
Issue
Section
Original Articles
Supporting Agencies
Armed Forces Institute of Pathology, Pakistan
Keywords:
Antimicrobial sensitivity, enteric fever, fluoroquinolones, Salmonella Typhi, Salmonella Paratyphi A
Statistics
  • Abstract views: 1313

  • PDF: 598
  • HTML: 497
How to Cite
Shujat, U., Ikram, A., Hashmi, I., Abbasi, S., Afzal, A., & Ayyub, M. (2016). Current antimicrobial sensitivity pattern of typhoidal salmonellae in a referral diagnostic centre. Microbiologia Medica, 31(1). https://doi.org/10.4081/mm.2016.4669