@article{Beaujois_Riquet_Cailliau_Browaeys-Poly_Russo_Blossey_Vicogne_Marin_Lescuyer-Rousseau_Vilain_Bodart_2013, title={Ultrasensitive MAPK/Erk activation in absence of protein synthesis in Xenopus oocytes}, volume={2}, url={https://www.pagepressjournals.org/mk/article/view/mk.2013.e2}, DOI={10.4081/mk.2013.e2}, abstractNote={The mitogen-activated protein kinase (MAPK) cascade in <em>Xenopus</em> oocytes exhibits an all-or-none, ultrasensitive response, which is believed to result from a positive feed-back loop. Here we describe a context where 1,10-phenanthroline slowly, but strongly, activates MAPK while it impairs protein synthesis in a zincdependent manner, abolishing any feed-back loop. The induced-MAPK response was found to be strongly ultrasensitive. We argue that underlying this behaviour is a regulation motif akin to a feed-forward loop acting <em>in vivo</em>.}, number={1}, journal={MAP Kinase}, author={Beaujois, Rémy and Riquet, Franck and Cailliau, Katia and Browaeys-Poly, Edith and Russo, Christophe and Blossey, Ralf and Vicogne, Dorothée and Marin, Matthieu and Lescuyer-Rousseau, Arlette and Vilain, Jean-Pierre and Bodart, Jean-François}, year={2013}, month={Jan.}, pages={e2} }