Control of the cell cycle progression by the MAPK Hog1

  • Josep Clotet Departament de Ciències Bàsiques, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain.
  • Joan Vendrell Unitat de Recerca; Hospital Universitari Joan XXIII, IISPV, Tarragona; CIBERDEM; Instituto de Salud Carlos III, Spain, Spain.
  • Xavier Escoté | xescote@gmail.com Unitat de Recerca; Hospital Universitari Joan XXIII, IISPV, Tarragona; CIBERDEM; Instituto de Salud Carlos III, Spain, Spain.

Abstract

Eukaryotic cells coordinate various intracellular activities in response to environmental stresses, activating an adaptive program to maximize the probability of survival and proliferation. Cells transduce diverse cellular stimuli by multiple mitogen-activated protein kinase (MAPK) cascades. MAPK are key signal transduction kinases required to respond to stress. A prototypical member of the MAPK family is the yeast high osmolarity glycerol (Hog1). Activation of Hog1 results in the generation of a set of adaptive responses that leads to the modulation of several aspects of cell physiology that are essential for cell survival, such as gene expression, translation, and morphogenesis. This review focuses on the control of cell cycle progression by Hog1 which is critical for cell survival in response to stress conditions.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2013-02-07
Info
Issue
Section
Review Articles
Supporting Agencies
Instituto de Salud Carlos III (ISCIII) FIS11/00085 and CIBERDEM
Keywords:
MAPK, Hog1, CDK, cell cycle, Sic1, Swe1, Hsl1, Cln1.
Statistics
  • Abstract views: 2722

  • PDF: 868
How to Cite
Clotet, J., Vendrell, J., & Escoté, X. (2013). Control of the cell cycle progression by the MAPK Hog1. MAP Kinase, 2(1), e3. https://doi.org/10.4081/mk.2013.e3