Electron microscopy to characterise nanoparticles in the biological environment

  • Mathieu Repellin Department of Neurosciences, Biomedicine and Movement Sciences, Section of Anatomy and Histology, University of Verona, Italy.
  • Flavia Carton | flavia.carton@univr.it Department of Neurosciences, Biomedicine and Movement Sciences, Section of Anatomy and Histology, University of Verona, Italy.

Abstract

Nowadays the use of nanomaterials has led a growing interest in biomedical application as drug delivery systems for the treatment and the diagnosis of different pathologies. Different analytical techniques have been applied to characterise nanoparticles in the biological environment. However, in the attempt to describe in detail the interaction of NPs with the living systems and to detect the possible occurrence of cell damage or death, electron microscopies proved to be especially suitable and actually are irreplaceable techniques thanks to their image resolution at the nanoscale. In this review article, the attention will first be focused on the influence of features on their interaction with tissues and cells; then, the advantages and limits of transmission and scanning electron microscopy to evaluate the suitability of nanovectors as drug-delivery systems will be discussed.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2019-04-01
Info
Issue
Section
Scientific Articles
Keywords:
Biodistribution, cellular uptake, drug delivery, nanomedicine
Statistics
  • Abstract views: 434

  • PDF: 149
How to Cite
Repellin, M., & Carton, F. (2019). Electron microscopy to characterise nanoparticles in the biological environment. Microscopie, 30(1). https://doi.org/10.4081/microscopie.2019.8188

Most read articles by the same author(s)