Cover Image

Gluten sensitivity and neurological manifestations

Agostino Berio, Giuseppe Mangiante, Gian Luigi Mariottini, Attilia Piazzi
  • Agostino Berio
    Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Mother’s and Pediatric Sciences, University of Genoa, Genoa, Italy | agostinoberio@ospedale-gaslini.ge.it
  • Giuseppe Mangiante
    Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Mother’s and Pediatric Sciences, University of Genoa, Genoa, Italy
  • Gian Luigi Mariottini
    Department of Earth, Environment and Life Sciences, University of Genoa, Genoa, Italy
  • Attilia Piazzi
    Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Mother’s and Pediatric Sciences, University of Genoa, Genoa, Italy

Abstract

The authors report on six cases of gluten-sensitivity, also defined non-celiac gluten sensitivity, characterized by abdominal features (diarrhea, bloating, pain), genetic positivity for predisposition to celiac disease (DQB1* 02 in all cases; DQA1*05 in three; DQA1*02 in two, DQB1*03 in two), negative anti-t-Transglutaminase antibodies, normal mucosa on biopsy in four cases, type 1 of Marsh in one case. The subjects presented frequent central nervous system (CNS) symptoms: headache in three patients, somnolence in one, electroencephalogram aspecific alterations in three (in two of them with previous seizures), leptomeningeal cyst in one, intracranial calcification in one, cerebral gliosis in two. After a gluten-free diet, all intestinal and clinical CNS features remitted, but re-appeared after gluten reintroduction. On the basis of the neurological signs, the authors stress the relevance of immune innate system in the pathogenesis of these cases with possible subsequent evolution on immune adaptive system involvement.

Keywords

Gluten sensitivity; Non-celiac gluten sensitivity; HLA; EEG; Gluten-free diet

Full Text:

PDF
Submitted: 2015-06-29 16:43:25
Published: 2015-12-17 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
720

Views:
PDF
557

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2015 Agostino Berio, Giuseppe Mangiante, Gian Luigi Mariottini, Attilia Piazzi

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2018     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185     •     Privacy