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Periodontitis is a chronic inflammatory disease causing destruction of supporting tissues of teeth. Even though the gramnegative anaerobes are essential for the initiation of periodontal destruction, multiple risk factors are essential for the progression of the disease. The genetic risk factor plays a significant role in the etiopathogenesis of periodontal disease. The innate immune mechanism is the first line of defense in screening and combating the invading periodontal pathogens. The genetic polymorphisms in the 3’UTR region of the innate immune signaling molecular factors like toll-like receptors, nod-like receptors and the polymorphisms in the epigenetic regulators of these factors like microRNA146a, apolipoproteinE might play an important role in the etiopathogenesis of periodontal destruction.
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