Diketopiperazine from marine bacterium Pseudoalteromonas ruthenica KLPp3

Faiq Sulieman; Asmat Ahmad; Gires Usup; Lu Chung Kuang

doi:10.4081/jbr.2018.7197

Diketopiperazine from marine bacterium Pseudoalteromonas ruthenica KLPp3

https://doi.org/10.4081/jbr.2018.7197

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Vol. 91 No. 1 (2018)

Submitted: November 17, 2017
Accepted: April 29, 2018

Published: May 17, 2018

Diketopiperazine, Sub-minimum inhibitory concentrations, Crude extract, Antibiofilm, Pseudoalteromonas ruthenica.

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Authors

Faiq Sulieman
faiq@siswa.ukm.edu.my
School of Bioscience and Biotechnology, University Kebangsaan Malaysia, Selangor, Malaysia.
Asmat Ahmad School of Bioscience and Biotechnology, University Kebangsaan Malaysia, Selangor, Malaysia.
Gires Usup School of Environmental Science and Natural Resources, University Kebangsaan Malaysia, Selangor, Malaysia.
Lu Chung Kuang National Research Institute of Chinese Medicine, Taipei, Taiwan.

Sub-minimum inhibitory concentration levels of Pseudoalteromonas ruthenica KLPp3 extract showed antibiofilm activity against Vibrio alginolyticus and Serratia marcescens. The KLPp3 crude extract was fractionated by thin layer chromatography, flash chromatography, solid phase extraction and semi-preparative high performance liquid chromatography. The pure compounds were then identified using H-nuclear magnetic resonance, C-nuclear magnetic resonance, 2D-nuclear magnetic Resonance and mass spectrometry. Nine fractions were collected from purification with two active fractions. One fractions were identified belong to the family of diketopiperazine.

Supporting Agencies

MOSTI

Sulieman, F., Ahmad, A., Usup, G., & Kuang, L. C. (2018). Diketopiperazine from marine bacterium Pseudoalteromonas ruthenica KLPp3. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 91(1). https://doi.org/10.4081/jbr.2018.7197