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Accuracy of serum markers, progesterone and vitamins measurements for early screening of abortions in the eastern region of Algeria (Batna)

Sara Mouffouk, Mouloud Yahia, Chaima Mouffouk, Hanane Boukrous, Aicha Saaidia, Fairouz Douha, Naima Achi
  • Sara Mouffouk
    Laboratory of Biotechnology of Bioactive Molecules and Cell Physiopathology, University of Batna 2 Mustapha Benboulaid, Algeria |
  • Mouloud Yahia
    Laboratory of Biotechnology of Bioactive Molecules and Cell Physiopathology, University of Batna 2 Mustapha Benboulaid, Algeria
  • Chaima Mouffouk
    Laboratory of Biotechnology of Bioactive Molecules and Cell Physiopathology, University of Batna 2 Mustapha Benboulaid, Algeria
  • Hanane Boukrous
    Laboratory of Biochemistry, Hospital of Batna, Algeria
  • Aicha Saaidia
    Obstetrics Gynecology Service, Hospital of Meriem Bouatoura-Batna, Algeria
  • Fairouz Douha
    Laboratory of Biotechnology of Bioactive Molecules and Cell Physiopathology, University of Batna 2 Mustapha Benboulaid, Algeria
  • Naima Achi
    Laboratory of Biochemistry, Hospital of Batna, Algeria


Spontaneous abortion is an involuntary interruption of pregnancy before 22 weeks of gestation. According to the Algerian National Institute of Public Health the percentage of women suffering from permanent complications during pregnancy is approximately 15%. The aim of this study is the determination of some biochemical analytes, including folic acid, vitamin B12, alphafoetoproteine, beta human chorionic gonadotropin (β-hCG), progesterone and oestradiol (uE3), which are involved in the detection of pregnancy failures. This case-control study was carried out on women in the process of abortion and a control group with viable pregnancies in the East region of Algeria (Batna) during the year 2015. In the present investigation, 69 pregnant women during the first and second trimester were recruited during the first and second trimesters as cases (with miscarriages) and the control group (n=69) was constituted of women who had normal ultrasound. The average concentration of alpha-fetoprotein is significantly low during the first trimester, but it is very high during the second trimester between cases and controls. The median values of β- hCG, uE3 and progesterone decrease very significantly. The mean concentration of serum folate and vitamin B12 did not change significantly between cases and controls in the first and second trimesters. The results of this study revealed that, spontaneous abortions are associated with changes in serum markers and progesterone, which could form an important part in the early diagnosis of non-viable pregnancies. However, vitamins levels have no significant effects on these pregnancies.


Serum markers; progesterone; vitamins (B9, B12); abortion

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Submitted: 2017-10-21 03:01:18
Published: 2018-02-12 16:16:15
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