A soluble form of CTLA-4 is present in serum of pediatric patients with acute lymphoblastic leukaemia
AbstractCTLA-4 can regulate and maintain self-telerance, providing a negative signal limiting immunoresponses. Acute lymphoblastic leukemia is a clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the presence of significantly elevated levels of a soluble form of CTLA-4 in 70% of B-ALL patients. A possible role of this soluble molecule in the pathogenesis of this neoplastic disease can be envisaged.
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Copyright (c) 2011 R. Simone, C. Tenca, F. Fais, G. De Rossi, G. Pesce, M. Bagnasco, D. Saverino
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