A soluble form of CTLA-4 is present in serum of pediatric patients with acute lymphoblastic leukaemia

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R. Simone
C. Tenca
F. Fais
G. De Rossi
G. Pesce
M. Bagnasco
D. Saverino *
(*) Corresponding Author:
D. Saverino | daniele.saverino@unige.it

Abstract

CTLA-4 can regulate and maintain self-telerance, providing a negative signal limiting immunoresponses. Acute lymphoblastic leukemia is a clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the presence of significantly elevated levels of a soluble form of CTLA-4 in 70% of B-ALL patients. A possible role of this soluble molecule in the pathogenesis of this neoplastic disease can be envisaged.

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