A soluble form of CTLA-4 is present in serum of pediatric patients with acute lymphoblastic leukaemia

Abstract

CTLA-4 can regulate and maintain self-telerance, providing a negative signal limiting immunoresponses. Acute lymphoblastic leukemia is a clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the presence of significantly elevated levels of a soluble form of CTLA-4 in 70% of B-ALL patients. A possible role of this soluble molecule in the pathogenesis of this neoplastic disease can be envisaged.

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Published
2011-01-30
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Abstract Book
Keywords:
soluble CTLA-4, acute lymphoblatic leukemia
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How to Cite
Simone, R., Tenca, C., Fais, F., De Rossi, G., Pesce, G., Bagnasco, M., & Saverino, D. (2011). A soluble form of CTLA-4 is present in serum of pediatric patients with acute lymphoblastic leukaemia. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 84(1). https://doi.org/10.4081/jbr.2011.4665