BT3 molecules ligation enhances the proinflammatory responses of human monocytes and monocyte-derived dendritic cells

Main Article Content

R. Simone
A. Rabellino
G. Icardi
M. Bagnasco
G. Pesce
D. Olive
D. Saverino *
(*) Corresponding Author:
D. Saverino | daniele.saverino@unige.it

Abstract

BT3, a new family of immunoreceptors, belongs to the extended B7 family. BT3 are expressed on the surface of resting and activated monocytes and monocytes-derived dendritic cells (iDC). We show that BT3 cross-linking, in the absence of other survival factors, provides a survival signal for monocytes. We further analysed the effects of BT3 cross-linking on various proinflammatory responses. Results obtained showed that BT3 engagements is able to modulate production of IL8/CXCL8, IL-I b and IL-I 2/p70. Moreover, we demostrated a co-stimulatory effect of BT3 receptors.

Downloads month by month

Downloads

Download data is not yet available.

Article Details

Most read articles by the same author(s)