BT3 molecules ligation enhances the proinflammatory responses of human monocytes and monocyte-derived dendritic cells

Abstract

BT3, a new family of immunoreceptors, belongs to the extended B7 family. BT3 are expressed on the surface of resting and activated monocytes and monocytes-derived dendritic cells (iDC). We show that BT3 cross-linking, in the absence of other survival factors, provides a survival signal for monocytes. We further analysed the effects of BT3 cross-linking on various proinflammatory responses. Results obtained showed that BT3 engagements is able to modulate production of IL8/CXCL8, IL-I b and IL-I 2/p70. Moreover, we demostrated a co-stimulatory effect of BT3 receptors.

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Published
2011-01-30
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Keywords:
BT3, B7 family, monocytes, dendritic cells, Toll-like receptors
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How to Cite
Simone, R., Rabellino, A., Icardi, G., Bagnasco, M., Pesce, G., Olive, D., & Saverino, D. (2011). BT3 molecules ligation enhances the proinflammatory responses of human monocytes and monocyte-derived dendritic cells. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 84(1). https://doi.org/10.4081/jbr.2011.4664

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