Protective effects of Resveratrol in an experimental model of abdominal aortic aneurysm induction
AbstractResveratrol (Rsv) is a natural antioxidant polyphenol with vasoprotective properties. We evaluated whether Rsv affects the inflammatory response in an experimental model of elastase-induced abdominal aortic aneurysm. Thirty male rats were subjected to aneurysm induction and treated or not with Rsv. Circulating levels of CD62L-monocyte subset, monocyte CD I 43 surface expression, MMP-9 plasma activity and TNFα serum levels were lower in Rsv-treated rats. In conclusion. Rsv acts as an anti-inflammatory compound and could be of great revelance to improve the immune response in AAA patients.
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Copyright (c) 2011 D. Palmieri, C. Barisione, C, Pane, G. Spinella, S. Garibaldi, G. Ghigliotti, C. Brunelli, E. Fulcheri, D. Palombo
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