Protective effects of Resveratrol in an experimental model of abdominal aortic aneurysm induction

  • D. Palmieri | danielapalmieri@yahoo.it
  • C. Barisione
  • C, Pane
  • G. Spinella
  • S. Garibaldi
  • G. Ghigliotti
  • C. Brunelli
  • E. Fulcheri
  • D. Palombo

Abstract

Resveratrol (Rsv) is a natural antioxidant polyphenol with vasoprotective properties. We evaluated whether Rsv affects the inflammatory response in an experimental model of elastase-induced abdominal aortic aneurysm. Thirty male rats were subjected to aneurysm induction and treated or not with Rsv. Circulating levels of CD62L-monocyte subset, monocyte CD I 43 surface expression, MMP-9 plasma activity and TNFα serum levels were lower in Rsv-treated rats. In conclusion. Rsv acts as an anti-inflammatory compound and could be of great revelance to improve the immune response in AAA patients.

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Published
2011-01-30
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Abstract Book
Keywords:
Andominal aortic aneurysm, Monocytes, MMPs, TNF-α
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How to Cite
Palmieri, D., Barisione, C., Pane, C., Spinella, G., Garibaldi, S., Ghigliotti, G., Brunelli, C., Fulcheri, E., & Palombo, D. (2011). Protective effects of Resveratrol in an experimental model of abdominal aortic aneurysm induction. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 84(1). https://doi.org/10.4081/jbr.2011.4638

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