Protective effects of Resveratrol in an experimental model of abdominal aortic aneurysm induction


Submitted: July 30, 2014
Accepted: July 30, 2014
Published: January 30, 2011
Abstract Views: 787
PDF: 349
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Resveratrol (Rsv) is a natural antioxidant polyphenol with vasoprotective properties. We evaluated whether Rsv affects the inflammatory response in an experimental model of elastase-induced abdominal aortic aneurysm. Thirty male rats were subjected to aneurysm induction and treated or not with Rsv. Circulating levels of CD62L-monocyte subset, monocyte CD I 43 surface expression, MMP-9 plasma activity and TNFα serum levels were lower in Rsv-treated rats. In conclusion. Rsv acts as an anti-inflammatory compound and could be of great revelance to improve the immune response in AAA patients.

Palmieri, D., Barisione, C., Pane, C., Spinella, G., Garibaldi, S., Ghigliotti, G., Brunelli, C., Fulcheri, E., & Palombo, D. (2011). Protective effects of Resveratrol in an experimental model of abdominal aortic aneurysm induction. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 84(1). https://doi.org/10.4081/jbr.2011.4638

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