Effects of PCB mixtures on recognized targets of endocrine disrupters exposure: search for early biomarkers

L. Stecca; C. La Rocca; S. Tait; A. Mantovani

doi:10.4081/jbr.2011.4628

Effects of PCB mixtures on recognized targets of endocrine disrupters exposure: search for early biomarkers

https://doi.org/10.4081/jbr.2011.4628

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Vol. 84 No. 1 (2011)

Submitted: July 29, 2014
Accepted: July 29, 2014

Published: January 30, 2011

Abstract Views: 645

PDF: 427

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Authors

Polychlorinated Biphenyls (PCBs) are Endocrine Disrupters (EDs) relevant to human dietary exposure. Since liver is the main organ involved in metabolism, a human hepatoblastoma cell line (HuH6) was used as in vitro model. A panel of nuclear receptors (NRs) was selected as early markers of PCBs exposure and analysed by qPCR. PCB congeners, grouped in three mixtures according to similarities in the modes of action, were used at the concentrations derived from previous data on human internal exposure. Preliminary results indicated that PCB mixtures exert different NRs modulations in HuH6.

Stecca, L., La Rocca, C., Tait, S., & Mantovani, A. (2011). Effects of PCB mixtures on recognized targets of endocrine disrupters exposure: search for early biomarkers. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 84(1). https://doi.org/10.4081/jbr.2011.4628