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Improving maintenance medication adherence in adult inflammatory bowel disease patients: a pilot study

Michelle L. Matteson-Kome, Jessica Winn, Matthew L. Bechtold, Jack D. Bragg, Cynthia L. Russell
  • Michelle L. Matteson-Kome
    Division of Gastroenterology and Hepatology, Sinclair School of Nursing, University of Missouri, Columbia, MO, United States | mattesonml@health.missouri.edu
  • Jessica Winn
    Department of Internal Medicine, University of Missouri, Columbia, MO, United States
  • Matthew L. Bechtold
    Division of Gastroenterology and Hepatology, Sinclair School of Nursing, University of Missouri, Columbia, MO, United States
  • Jack D. Bragg
    Division of Gastroenterology and Hepatology, Sinclair School of Nursing, University of Missouri, Columbia, MO, United States
  • Cynthia L. Russell
    School of Nursing, University of Missouri-Kansas City, MO, United States

Abstract

Medication nonadherence in inflammatory bowel disease (IBD) may lead to suboptimal control of the disease, decreased quality of life, and poor outcomes. This pilot study evaluated the feasibility, intervention mechanism, and potential effectiveness of a three-month continuous self-improvement (CSI) intervention to enhance medication adherence (MA) in adult nonadherent IBD patients. Adult IBD patients taking a daily or twice-daily dosed maintenance medication were screened electronically for two months to determine baseline MA levels. Nonadherent IBD participants were randomized to the CSI or the attention control (AC) intervention and monitored for three months. The CSI intervention consisted of a data evaluation and system refinement process in which system changes were identified and implemented. The AC group was given educational information regarding IBD disease process, extra-intestinal manifestations of IBD, and medical therapy. Demographic statistics, change scores for within and between- group differences, and effect size estimates were calculated. Nine nonadherent participants (medication adherence score <0.85) were eligible for randomization. The intervention was found feasible and acceptable. Although no statistically significant improvement in MA was found (P=0.14), adherence improved in 3 of 4 of the CSI group and 1 of 2 in the attention control group. The effect size calculation of 1.9 will determine the sample size for future study. The results of this pilot study showed the intervention was feasible and had a positive effect on MA change score and adherence levels. A larger fully powered study is needed to test of the effectiveness of this innovative intervention.

Keywords

adherence, inflammatory bowel disease, intervention

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Submitted: 2013-02-18 18:10:24
Published: 2014-01-13 15:20:03
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Copyright (c) 2014 Michelle L. Matteson-Kome, Jessica Winn, Matthew L. Bechtold, Jack D. Bragg, Cynthia L. Russell

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